| Cat. No. |
Product Name |
Information |
| PC-22144 |
PF-06447475
LRRK2 inhibitor
|
PF-06447475 is a highly potent, selective and brain penetrant LRRK2 inhibitor with IC50 of 3 nM, also inhibits STE20 kinase family MST1/MST2 with IC50 of 22 nM (MST2). |
| PC-21888 |
EB-42168
G2019S-LRRK2 inhibitor
|
EB-42168 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 1.1 nM (pS935-LRRK2) in FRET-based assay, >100-fold selective over WT-LRRR2. |
| PC-49826 |
Lu AF58786
LRRK2 inhibitor
|
Lu AF58786 is a potent and selective LRRK2 inhibitor with IC50 of 12 nM, 19 nM and 93 nM for LRRK2 WT, LRRK2-G2019S and LRRK2-A2016T in cell-based assays, respectively. |
| PC-49823 |
LRRK2 inhibitor 25
LRRK2 inhibitor
|
LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM. |
| PC-49822 |
LRRK2 GTP binding inhibitor 68
LRRK2 inhibitor
|
LRRK2 GTP binding inhibitor 68 is a potent, GTP binding inhibitor of LRRK2 with IC90 of 10 nM, inhibits LRRK2 GTP binding and kinase activities. |
| PC-49821 |
FX2149
LRRK2 inhibitor
|
FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP. |
| PC-49302 |
G2019S-LRRK2 inhibitor 22
G2019S-LRRK2 inhibitor
|
G2019S-LRRK2 inhibitor 22 is a novel potent, BBB-penetrant, G2019S-LRRK2 selective kinase inhibitor with IC50 of 4.6 nM, >700-fold selectivity over WT LRRK2. |
| PC-38909 |
DNL201
LRRK2 inhibitor
|
DNL201 (GNE0877) is a first-in-class, CNS-penetrant, selective, ATP-competitive, small-molecule LRRK2 kinase inhibitor with IC50 of 3 nM. |
| PC-72161 |
G2019S-LRRK2 inhibitor 38
G2019S-LRRK2 inhibitor
|
G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM). |
| PC-72160 |
EB-42486
G2019S-LRRK2 inhibitor
|
EB-42486 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 3.1 nM (pS935-LRRK2) in FRET-based assay, >300-fold selective over WT-LRRR2. |
| PC-43416 |
GSK2578215A
LRRK2 inhibitor
|
GSK2578215A is a highly potent, selective, BBB-permeable LRRK2 inhibitor with IC50 of 10.9 and 9.9 nM for wild-type LRRK2 and the G2019S mutant, respectively. |
| PC-42945 |
GNE-9605
LRRK2 inhibitor
|
GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM. |
