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Chemical Structure : FX2149
CAS No.: 1842427-90-0
Catalog No.: PC-49821Not For Human Use, Lab Use Only.
FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP.
FX2149 potently inhibits LRRK2 GTP binding and kinase activity in vitro.
FX2149 at 100 nM concentration significantly reduced G2019S-LRRK2 phosphorylation at residues S935 and S2032 by 90% in cell-free assays.
FX2149 (100 nM) attenuated G2019S-LRRK2-induced neuronal degeneration in SH-SY5Y cells.
FX2149 (10 mg/kg) is more efficient in reducing LRRK2 GTP binding and kinase activities in transgenic mice brains than LRRK2 inhibitor 68.
FX2149 (10 mg/kg) reduced LPS-induced microglia activation and LRRK2 upregulation in mice.
FX2149 attenuates LRRK2-R1441C-induced mitochondrial and lysosomal transport impairments.
| M.Wt | 319.38 | |
| Formula | C15H17N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-Propyl-3-(pyridine-3-sulfonamido)benzamide |
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1. Li T, et al. PLoS One. 2015 Mar 27;10(3):e0122461.
2. Thomas JM, et al. Front Aging Neurosci. 2017 Jan 10;8:337.
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