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Request The Product List ofExportin-1 (CRM1,XPO1) Exportin-1 (CRM1,XPO1)

Cat. No. Product Name Information
PC-49222

KPT-276

CRM1 inhibitor

KPT-276 (KPT276) is an orally bioavailable selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this protein, shows antileukemic activity in vitro and in vivo in acute myeloid leukemia (AML).
PC-49221

KPT-185

CRM1 inhibitor

KPT-185 (KPT185) is a potent, selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this protein, shows antileukemic activity in vitro and in vivo in acute myeloid leukemia (AML).
PC-49183

LFS-829

CRM1 inhibitor

LFS-829 (LFS829) is a potent, covalent, small-molecule antagonist of exportin-1 (CRM1) with binding Kd values of 26.95 nM in SPR assays, forms a covalent bond with the sulfur atom of Cys539 126 located in the NES binding cleft of CRM1.
PC-35933

Verdinexor

CRM1 inhibitor

Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively.
PC-35581

Selinexor

CRM1 inhibitor

Selinexor (KPT-330, KPT330) is a potent, orally available, selective inhibitor of nuclear export (SINE) targeting CRM1 (XPO1).
PC-61270

KPT-251

CRM1 inhibitor

KPT-251 (KPT251) is a small-molecule, selective inhibitor of nuclear export (CRM1 inhibitor, SINE) that exhibits potent antileukemic activity.
PC-70229

Leptomycin B

CRM1 inhibitor

Leptomycin B (CI 940, Elactocin, Mantuamycin) is a potent and specific nuclear export inhibitor that binds to and inhibits CRM1 (XPO1).
PC-42151

KPT-8602 Z-isomer

CRM1 inhibitor

KPT-8602 Z-isomer is the Z-isomer of Eltanexor (KPT-8602), which is a second-generation SINE with markedly reduced brain penetration compared to selinexor.
PC-42150

Eltanexor

CRM1 inhibitor

Eltanexor (KPT-8602) is a second-generation SINE, orally bioavailable Exportin 1 (XPO1,CRM1) inhibitor with markedly reduced brain penetration compared to selinexor (30-fold less).
PC-23458

CBS9106

CRM1 inhibitor

CBS9106 (Felezonexor) is a reversible oral CRM1/exportin1 inhibitor, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a broad spectrum of cancer cells.
PC-23457

SZJK-0421

CRM1 inhibitor

SZJK-0421 is a potent, selective second-generation reversible exportin-1 (CRM1) inhibitor with IC50 of 87.1 nM against MM1S cells.

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