Chemical Structure : CRM1 inhibitor S109
CAS No.:
1076234-33-7
CRM1 inhibitor S109
Catalog No.: PC-23730Not For Human Use, Lab Use Only.
CRM1 inhibitor S109 is a specific, reversible inhibitor of CRM1 (exportin 1, XPO1), inhibits cell viability with IC50 of 1.2 uM and 0.97 μM in HCT-15 and HT-29 cells, can induce CRM1 protein degradation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CRM1 inhibitor S109 is a specific, reversible inhibitor of CRM1 (exportin 1, XPO1), inhibits cell viability with IC50 of 1.2 uM and 0.97 μM in HCT-15 and HT-29 cells, can induce CRM1 protein degradation.
S109 significantly inhibits colorectal cells proliferation and invasion and concomitantly induces cell cycle arrest.
S109 inhibits CRM1 function and induces nuclear retention of tumor suppress proteins.
S109 decreases CRM1 protein expression via proteasomal-mediated degradation.
S109 significantly prolonged the survival in mouse models of malignant glioma.
Physicochemical Properties
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M.Wt
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319.67
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Formula
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C12H9ClF3N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-((6-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-3,4-dimethyl-1H-pyrrole-2,5-dione
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References
1. Xuejiao Liu, et al. J Hematol Oncol. 2016 Oct 12;9(1):108.
2. Niu M, et al. Cancer Biol Ther. 2015;16(7):1110–1118.
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