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Cat. No. Product Name Information
PC-38836

Z640

aPKC agonist

Z640 is a novel non-selective atypical PKC (aPKC) agonist, increases PKCζ and PKCι kinase activity with EC50 of 1.09 and 3.47 µM in vitro kinase activity assays, respectively.
PC-38356

Darovasertib

PKC inhibitor

Darovasertib (NVP-LXS196, LXS 196, IDE 196) is a potent, selectve, oral pan- protein kinase C (PKC) inhibitor with IC50 of 3 nM and 0.6 nM for PKCα and PKCθ, respectively.
PC-73059

NP627

PKCδI inhibitor

NP627 (NP-627) is a specific small-molecule inhibitor of protein kinase C deltaI (PKCδI) with Kd of 1 nM.
PC-73053

PKCθ inhibitor 22

PKCθ inhibitor

PKCθ inhibitor 22 is a potent, selective, orally bioavailable inhibitor of Protein Kinase Cθ (PKCθ) with IC50 of 6 nM.
PC-72784

CC-90005

PKC-θ inhibitor

CC-90005 (CC90005) is a potent, selective PKC-θ inhibitor with IC50 of 8 nM, >500-fold selectivity over PKC-γ.
PC-38022

TPPB

PKC activator

TPPB is a highly potent, selectiveand cell permeable protein kinase C (PKC) activator with Ki of 11.9 nM.
PC-36023

PZ09

PKC-zeta inhibitor

PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold).
PC-35337

ζ-Stat

PKC-zeta inhibitor

ζ-Stat (1,3,6-Naphthalenetrisulfonic acid) is a novel PKC-zeta (PKC-ζ) specific inhibitor with IC50 of 5 uM, shows only 13% inhibition on PKC-I at 20 uM.
PC-35336

ICA-1

PKC-iota inhibitor

ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member.
PC-63489

PKCiota-IN-49

PKCiota-IN-49 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.8 nM, >20-fold selectivity over PKC-α (IC50=71 nM) and PKC-β (IC50=350 nM).
PC-63224

PKCα/β inhibitor Cmpd 1

PKCα/β inhibitor

PKCα/β inhibitor Cmpd 1 is a potent and selective inhibitor of Protein Kinase C (PKC) family members PKCα and PKCβ with IC50 of 2 nM and 11 nM, respectively.
PC-42863

Chelerythrine chloride

PKC inhibitor

Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL.

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