| Cat. No. |
Product Name |
Information |
| PC-38836 |
Z640
aPKC agonist
|
Z640 is a novel non-selective atypical PKC (aPKC) agonist, increases PKCζ and PKCι kinase activity with EC50 of 1.09 and 3.47 µM in vitro kinase activity assays, respectively. |
| PC-38356 |
Darovasertib
PKC inhibitor
|
Darovasertib (NVP-LXS196, LXS 196, IDE 196) is a potent, selectve, oral pan- protein kinase C (PKC) inhibitor with IC50 of 3 nM and 0.6 nM for PKCα and PKCθ, respectively. |
| PC-73059 |
NP627
PKCδI inhibitor
|
NP627 (NP-627) is a specific small-molecule inhibitor of protein kinase C deltaI (PKCδI) with Kd of 1 nM. |
| PC-73053 |
PKCθ inhibitor 22
PKCθ inhibitor
|
PKCθ inhibitor 22 is a potent, selective, orally bioavailable inhibitor of Protein Kinase Cθ (PKCθ) with IC50 of 6 nM. |
| PC-72784 |
CC-90005
PKC-θ inhibitor
|
CC-90005 (CC90005) is a potent, selective PKC-θ inhibitor with IC50 of 8 nM, >500-fold selectivity over PKC-γ. |
| PC-38022 |
TPPB
PKC activator
|
TPPB is a highly potent, selectiveand cell permeable protein kinase C (PKC) activator with Ki of 11.9 nM. |
| PC-36023 |
PZ09
PKC-zeta inhibitor
|
PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold). |
| PC-35337 |
ζ-Stat
PKC-zeta inhibitor
|
ζ-Stat (1,3,6-Naphthalenetrisulfonic acid) is a novel PKC-zeta (PKC-ζ) specific inhibitor with IC50 of 5 uM, shows only 13% inhibition on PKC-I at 20 uM. |
| PC-35336 |
ICA-1
PKC-iota inhibitor
|
ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member. |
| PC-63489 |
PKCiota-IN-49
|
PKCiota-IN-49 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.8 nM, >20-fold selectivity over PKC-α (IC50=71 nM) and PKC-β (IC50=350 nM). |
| PC-63224 |
PKCα/β inhibitor Cmpd 1
PKCα/β inhibitor
|
PKCα/β inhibitor Cmpd 1 is a potent and selective inhibitor of Protein Kinase C (PKC) family members PKCα and PKCβ with IC50 of 2 nM and 11 nM, respectively. |
| PC-42863 |
Chelerythrine chloride
PKC inhibitor
|
Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL. |
