| Cat. No. |
Product Name |
Information |
| PC-72802 |
TAK-981
|
TAK-981 (TAK981, Subasumstat) is a first-in-class, potent, highly selective SUMO-activating enzyme (SAE) inhibitor with IC50 of 1 nM, >1000-fold selectivity against UAE and NAE. |
| PC-35900 |
COH000
|
COH000 (COH-000) is a highly selective, first-in-class, irreversible, allosteric, covalent inhibitor of SUMO-Activating Enzyme E1, inhibits SUMOylation in vitro with IC50 of 0.2 uM, displays >500-fold selectivity for SUMOylation over ubiquitylation. |
| PC-60355 |
IJ-5
|
A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively. |
| PC-60350 |
ABP-A3
|
ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes. |
| PC-60178 |
TAK-243
|
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1) with IC50 of 1 nM. |
| PC-20624 |
DKM 2-93
|
DKM 2-93 is a covalent, relatively selective inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5) with IC50 of 430 uM, binds to the catalytic cysteine of UBA5 cysteine 250 (C250). |
| PC-43475 |
PYZD-4409
|
PYZD-4409 is a specific inhibitor of ubiquitin-activating enzyme (E1) with IC50 of 20 uM, inhibits the ATP-dependent activation of ubiquitin and subsequent transfer of the activated ubiquitin from the E1 to the common human E2 enzyme UBE2E2. |
