| Cat. No. |
Product Name |
Information |
| PC-72802 |
TAK-981
SUMOylation inhibitor
|
TAK-981 (TAK981, Subasumstat) is a first-in-class, potent, highly selective SUMO-activating enzyme (SAE) inhibitor with IC50 of 1 nM, >1000-fold selectivity against UAE and NAE. |
| PC-35900 |
COH000
SUMOylation inhibitor
|
COH000 (COH-000) is a highly selective, first-in-class, irreversible, allosteric, covalent inhibitor of SUMO-Activating Enzyme E1, inhibits SUMOylation in vitro with IC50 of 0.2 uM, displays >500-fold selectivity for SUMOylation over ubiquitylation. |
| PC-43475 |
PYZD-4409
UBA1 inhibitor
|
PYZD-4409 is a specific inhibitor of ubiquitin-activating enzyme UBA1 with IC50 of 20 uM. |
| PC-43474 |
PYR-41
UAE1 inhibitor
|
PYR-41 is a selective, cell-permeable inhibitor of ubiquitin-activating enzyme (E1), blocks loading of immobilized His6-tagged E1 with ubiquitin with IC50 of <10 uM. |
| PC-61698 |
ML-792
SUMOylation inhibitor
|
ML-792 is a potent, seletive SUMO-activating enzyme (SAE) inhibitor with IC50 of 3 nM and 11 nM for SAE/SUMO1 and SAE/SUMO2, respectively. |
| PC-60355 |
IJ-5
UbcH5 inhibitor
|
A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively. |
| PC-60354 |
UbcH5c-IN-6d
UbcH5c inhibitor
|
UbcH5c-IN-6d is a potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM. |
| PC-60351 |
ABP1
SUMOylation inhibitor
|
ABP1 is a nonselective inhibitor of UBL protein-activating E1 enzymes that forms covalent adducts with UBL proteins SUMO1, ubiquitin, Nedd8, ISG15, and GABARAP in the presence of ATP and E1 enzymes in vitro. |
| PC-60178 |
TAK-243
UAE1 inhibitor
|
TAK-243 (MLN7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1) with IC50 of 1 nM. |
| PC-20624 |
DKM 2-93
UBA5 inhibitor
|
DKM 2-93 is a covalent, relatively selective inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5) with IC50 of 430 uM, binds to the catalytic cysteine of UBA5 cysteine 250 (C250). |
