| Cat. No. |
Product Name |
Information |
| PC-25068 |
AB8939
Tubulin polymerization inhibitor
|
AB8939 is a next-generation small-molecule tubulin polymerization inhibitor, binds to tubulin and induces a rapid destabilisation of microtubules. |
| PC-23848 |
Epothilone D
Microtubule stabilizer
|
Epothilone D (Utidelone, Desoxyepothilone B, KOS 862) is a potent microtubule stabilizer, inhibits CCRF-CEM/VBL1000 cells (2,048-fold resistance to vinblastine) with IC50 of 2.9 nM. |
| PC-22895 |
MI-181
M-phase inhibitor
|
MI-181 (Mitotic inhibitor-181) is a potent M-phase inhibitor with mitotic arrest IC50 of 23 nM and cell death IC50 of 17 nM, inhibits tubulin polymerization and modulates cilia length and biogenesis. |
| PC-21390 |
Plinabulin
Tubulin inhibitor
|
Plinabulin (NPI-2358) is a small molecule vascular disrupting agent against tubulin-depolymerizing, shows IC50 of 9.8 nM against HT-29 cells. |
| PC-20673 |
EAPB02303
Microtubule inhibitor
|
EAPB02303 (EAPB 02303) is a novel microtubule-disrupting agent with in-vivo activity in PDAC and in-vitro synergy with Paclitaxel, inhibits A375 melanoma cell line with IC50 of 3 nM. |
| PC-49251 |
ELR510444
Microtubule disruptor
|
ELR510444 (ELR-510444) is a small molecule microtubule disruptor that directly interacts with tubulin at the colchicine-binding site, shows potent microtubule-disrupting activity. |
| PC-49013 |
CH-3-8
Microtubule destabilizer
|
CH-3-8 is a novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance, binds to the colchicine-binding site in tubulin protein, disrupts microtubule dynamics at the nanomolar concentration in MIA PaCa-2 and PANC-1 pancreatic cancer cell lines. |
| PC-49011 |
QW-296
Microtubule destabilizer
|
QW-296 is a novel microtubule destabilizer with little susceptible to transporter-mediated drug resistance, disturbs the microtubule dynamics at the nanomolar concentration in A375 and B16F10 melanoma cells. |
| PC-47072 |
R-huezole
Tubulin modulator
|
R-huezole is a phase-separating small molecule that forms liquid droplets to selectively sequester tubulin, enters cultured human cells and prevents cell mitosis by forming tubulin-concentrating condensates in cells. |
| PC-38804 |
CH-2-77 analogue 60c
Tubulin inhibitor
|
CH-2-77 analogue 60c is a potent colchicine-binding site tubulin inhibitor, inhibits tubulin polymerization and is effective against P-glycoprotein-mediated multiple drug resistance and taxol resistance. |
| PC-38803 |
CH-2-77
Tubulin inhibitor
|
CH-2-77 is a potent colchicine-binding site inhibitor (CBSI) targeting tubulin, shows potent anti-proliferative activity against a panel of cancer cells in vitro and efficacious anti-tumor effects in vivo. |
| PC-38698 |
ALM201
Angiogenesis inhibitor, FKBP ligand
|
ALM201 is a small 23 amino acid peptide derived from the FK506 binding protein FKBPL, a targeted microtubule binding agent which exhibits potent anti-angiogenic activity in vitro and in vivo. |
