Chemical Structure : AB8939
CAS No.:
1974336-09-8
AB8939
(AB-8939)
Catalog No.: PC-25068Not For Human Use, Lab Use Only.
AB8939 is a next-generation small-molecule tubulin polymerization inhibitor, binds to tubulin and induces a rapid destabilisation of microtubules.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AB8939 is a next-generation small-molecule tubulin polymerization inhibitor, binds to tubulin and induces a rapid destabilisation of microtubules.
AB8939 shows broad anti-proliferative activity across the breath of acute myeloid leukemia (AML) subtypes.
AB8939 produces a strong anti-proliferative action against blasts isolated from AML patients with a majority of IC50 values ranging from 1.4 nM to 1.0 µM.
AB8939 demonstrates activity across the entire spectrum of AML subtypes, according to the French-American-British (FAB) AML classification, with an IC50 of < 50 nM in M0, M1, M4, M5 and M6 subtypes, corresponding to over 90% of the AML patient population.
AB8939 showed strong anti-leukemic activity in AMKL26 mouse model as evidenced by the near eradication of blasts.
Physicochemical Properties
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M.Wt
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Formula
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C22H24N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-Imidazolidinone, 1-[4-[2-[[5-(ethoxymethyl)-2-methylphenyl]amino]-5-oxazolyl]phenyl]-
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References
1. Armelle Goubard, et al. Blood (2019) 134 (Supplement_1): 5154.
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