| Cat. No. |
Product Name |
Information |
| PC-21486 |
EN171
14-3-3 modulator
|
EN171 is 14-3-3 molecular glue that covalently targets 14-3-3 to enhance 14-3-3 interactions with ERa (EC50=9 uM), YAP, and TAZ, impairs estrogen receptor and Hippo pathway transcriptional activity. |
| PC-38502 |
HS-1793
14-3-3 inhibitor
|
HS-1793 is a resveratrol derivative that overcomes the resistance conferred by Bcl-2 in U937 cells via 14-3-3, exhibits antitumor activity via Bad and marked downregulates 14-3-3 protein. |
| PC-72267 |
CU7218
14-3-3 inhibitor
|
CU7218 is a small-molecule inhibitor of 14-3-3 protein, inhibits the interaction between 9J10 and 14-3-3. |
| PC-62030 |
FOBISIN101
14-3-3 inhibitor
|
FOBISIN101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. |
| PC-61238 |
RB-011
14-3-3 inhibitor
|
RB-011 is a small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells. |
| PC-61233 |
Fusicoccin-A
14-3-3 modulator
|
Fusicoccin-A is a small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1. |
| PC-61232 |
Difopein
14-3-3 inhibitor
|
Difopein is a specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity. |
| PC-61231 |
14-3-3 inhibitor BV02
14-3-3 inhibitor
|
14-3-3 inhibitor BV02 is a novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. |
| PC-25264 |
14-3-3-ERα stabilizer 41
14-3-3/ERα stabilizer
|
14-3-3/ERα stabilizer 41 is a potent, selective and covalent small-molecule stabilizer of the 14-3-3σ/ERα complex, forms a covalent bond with C38 of 14-3-3σ, shows remarkable selectivity for 14-3-3σ/ERα (KD=10.1 nM). |
| PC-25263 |
14-3-3-ERα stabilizer 181
CAS 3057296-86-0
|
14-3-3/ERα stabilizer 181 is a potent, selective and covalent small-molecule stabilizer of the 14-3-3σ/ERα complex, forms a covalent bond with C38 of 14-3-3σ, shows remarkable selectivity for 14-3-3σ/ERα (appKD of 18 nM, 116-fold stabilization at 100 μM compound). |
| PC-25262 |
14-3-3-ERα stabilizer 127
CAS 3057296-45-1
|
14-3-3/ERα stabilizer 127 is a potent, covalent, small-molecule stabilizer of the 14-3-3σ/ERα complex with EC50 of 2.0 uM, forms a covalent bond with C38 of 14-3-3σ. |
| PC-24500 |
ChREBPα-14-3-3 PPI stabilizer 43
ChREBPα stabilizer
|
ChREBPα/14-3-3 PPI stabilizer 43 is a potent, specific molecular glue as ChREBPα/14-3-3 protein-protein interaction (PPI) stabilizer with EC50 of 3.8 uM, protect human β-cells from glucolipotoxicity. |
