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Difopein

Chemical Structure : Difopein

CAS No.: 396834-58-5

Difopein

Catalog No.: PC-61232Not For Human Use, Lab Use Only.

A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity; blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S, induces apoptosis of human glioma cells through down-regulating Bcl-2, up-regulating Bax and activating caspase-9 and caspase-3, and suppresses tumor growth in mice; also enhances the ability of cisplatin to kill cells.

Physicochemical Properties

M.Wt 6387.17
Formula C273H424N76O89S6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE

References

1. Masters SC, et al. J Biol Chem. 2001 Nov 30;276(48):45193-200.

2. Lalle M, et al. J Biol Chem. 2006 Feb 24;281(8):5137-48.

3. Cao W, et al. Apoptosis. 2010 Feb;15(2):230-41.

4. Foote M, et al. Biol Psychiatry. 2015 Sep 15;78(6):386-95.

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