| Cat. No. |
Product Name |
Information |
| PC-24644 |
BBO-10203
RAS-PI3Kα inhibitor
|
BBO-10203 is a first-in-class inhibitor of the RAS-PI3Kα interaction, binds specifically and cocalently to the RBD of PI3Kα (IC50=3 nM), disrupts PI3Kα interaction with K-,H-, and N-RAS with low single digit nanomolar potency (5 nM). |
| PC-23222 |
CHF-6523
PI3Kδ inhibitor
|
CHF-6523 is a potent, selective and inhaled PI3Kδ inhibitor with enzymatic pKi value of 9.07 and pIC50 of 8.78 in THP-1 assay. |
| PC-23166 |
Linperlisib
PI3Kδ inhibitor
|
Linperlisib (YY-20394) is a potent, selective and orally active PI3Kδ inhibitor (IC50=4.6 nM), inhibitr PI3Kδ expressing human tumor cells growth both in vitro and in vivo. |
| PC-22488 |
Taselisib
PI3Kα inhibitor
|
Taselisib (GDC-0032, RG-7604) is a potent, selective inhibitor of PIK3CA (PI3Kα) with Ki of 0.29 nM and pAkt IC50 of 4 nM, 31-fold selective over PI3Kβ. |
| PC-22458 |
AS-252424
PI3Kγ inhibitor
|
AS-252424 is a potent, and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 30 nM, 30-fold selective over PI3Kα, also is a potent ferroptosis inhibitor targeting ACSL4. |
| PC-22175 |
KTC1101
pan-PI3K inhibitor
|
KTC1101 is a potent, selective pan-PI3K inhibitor with IC50 of 3.72 nM for PI3Kα, 36.29 nM for PI3Kβ, 1.22 nM for PI3Kδ, and 17.09 nM for PI3Kγ. |
| PC-21944 |
GSK2636771
PI3Kβ inhibitor
|
GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with Ki/IC50 of 0.89/5.2 nM, respectively. |
| PC-21298 |
RLY-2608
PI3Kα H1047R inhibitor
|
RLY-2608 (RLY2608) is a first-in-class, allosteric, mutant-selective inhibitor of PI3Kα with IC50 of 4 nM (PI3Kα H1047R), 12-fold selective over PI3Kα WT. |
| PC-21139 |
STX-478
PI3Kα H1047R inhibitor
|
Tersolisib (STX-478, STX478) is a potent, mutant-selective, allosteric PI3Kα inhibitor with IC50 of 9.4 nM (PI3Kα H1047R), 14-fold selectivity over WT PI3Kα (IC50=131 nM). |
| PC-20848 |
UCL-TRO-1938
PI3Kα activator
|
UCL-TRO-1938 (Compound 1938) is a selective, allosteric activator of PI3Kα with EC50 of 60 uM (based on in vitro lipid kinase activity), directly activates PI3Kα signalling in cells. |
| PC-20591 |
IOA-244
PI3Kδ inhibitor
|
IOA-244 (Roginolisib, MSC2360844) is a potent, selective and non-ATP-competitive PI3Kδ inhibitor with IC50 of 19 nM, selective over PI3Kβ (0.43 uM), Vps34 (9 uM) and PI3Kα (10.1 uM). |
| PC-20590 |
Alpelisib
PI3Kα inhibitor
|
Alpelisib (NVP-BYL719, BYL719) is ia potent, selective, and orally active PI3Kα inhibitor with IC50 of 5 nM, >50-fold selectivity over p110γ/p110δ/p110β. |
