| Cat. No. |
Product Name |
Information |
| PC-23005 |
PI3K-C2γ inhibitor 26
PI3K-C2γ inhibitor
|
PI3K-C2γ inhibitor 26 is a potent, isoform-selective inhibitor of PI3K-C2γ with IC50 of 340 nM, with no activity against class I and III PI3Ks or a panel of 60 other protein kinases. |
| PC-23004 |
MIPS-21335
PI3KC2α inhibitor
|
MIPS-19416 is a potent selective inhibitor of class II alpha PI3K (PI3K-C2α) with IC50 of 7 nM, six-fold selective over PI3K-C2β, 20-fold over PI3K-p110α. |
| PC-23003 |
MIPS-19416
PI3K inhibitor
|
MIPS-19416 is a potent dual class I and class II PI3Ks inhibitor with IC50 of 13 nM (PI3KC2α), equal to or more potent than against class I isoforms or against PI3KC2β (IC50=12-94 nM). |
| PC-23002 |
PITCOIN4
PI3KC2α inhibitor
|
PITCOIN4 is a potent, highly selective inhibitor of class II alpha PI3K (PI3K-C2α) with IC50 of 56 nM, >100-fold selectivity over PI3K-C2β. |
| PC-22536 |
TYM-3-98
PI3Kδ inhibitor
|
TYM-3-98 is a potent, selective inhibitor of PI3Kδ (PI3Kdelta) with IC50 of 7.1 nM, highly selective over other PI3K isoforms at both molecular and cellular levels. |
| PC-22488 |
Taselisib
PI3Kα inhibitor
|
Taselisib (GDC-0032) is a potent, selective inhibitor of PIK3CA (PI3Kα) with Ki of 0.29 nM and pAkt IC50 of 4 nM, 31-fold selective over PI3Kβ. |
| PC-22090 |
QR-7909
PI3Kα H1047R inhibitor
|
QR-7909 is a potent, specific and allosteric PI3Kα H1047R inhibitor with IC50 of 51 nM, 27-fold selective over WT PI3Kα in biochemical assays. |
| PC-21948 |
PIK-108
p110β inhibitor
|
PIK-108 is a potent, selective and allosteric PI3K p110β inhibitor with IC50 of 57 nM, 45-fold selective over PI3Kα (IC50=2600 nM). |
| PC-21947 |
PI3Kα H1047R inhibitor 17
H1047R PI3Kα inhibitor
|
PI3Kα H1047R inhibitor 17 is a potent, selective H1047R PI3Kα mutant inhibitor with IC50 of 1 nM (inhibition of pAKT formation), without effect on PI3Kα WT. |
| PC-21944 |
GSK2636771
PI3Kβ inhibitor
|
GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with Ki/IC50 of 0.89/5.2 nM, respectively. |
| PC-20568 |
Zandelisib
p110δ inhibitor
|
Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase p110δ with IC50 of 3.5 nM. |
| PC-20451 |
PITCOIN2
PI3KC2α inhibitor
|
PITCOIN2 (LU-06-006) is a potent selective PI3KC2α inhibitor with IC50 of 126 nM, has selectivity against PI3KC2γ but shows micromolar activity on PI3KC2β. |
