| Cat. No. |
Product Name |
Information |
| PC-23729 |
JN-KI3
PI3Kγ inhibitor
|
JN-KI3 is a potent, selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 3.87 uM, with no actiivity against PI3Kα, PI3Kβ and PI3Kδ (IC50>20 uM). |
| PC-23245 |
Menadione sodium bisulfite
Vps34 inhibitor
|
Menadione sodium bisulfite (MSB) is a water-soluble form of vitamin K precursor menadione, suppresses prostate cancer growth by targeting the kinase VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3). |
| PC-23119 |
AS041164
PI3Kγ inhibitor
|
AS041164 is a potent, selective and orally bioavailable PI3Kγ inhibitor with IC50 of 70 nM, blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation. |
| PC-23007 |
PITCOIN1
PI3KC2α inhibitor
|
PITCOIN1 is a potent, highly selective inhibitor of class II alpha PI3K (PI3K-C2α) with IC50 of 100 nM, with no activity against class I and III PI3Ks. |
| PC-23006 |
PI-701
PI3KC2β inhibitor
|
PI-701 (YM185453) is a selective inhibitor of class II PI3KC2β isoform with IC50 of 528 nM, does not display activity toward PI3K class I isoforms. |
| PC-23005 |
PI3K-C2γ inhibitor 26
PI3K-C2γ inhibitor
|
PI3K-C2γ inhibitor 26 is a potent, isoform-selective inhibitor of PI3K-C2γ with IC50 of 340 nM, with no activity against class I and III PI3Ks or a panel of 60 other protein kinases. |
| PC-23004 |
MIPS-21335
PI3KC2α inhibitor
|
MIPS-19416 is a potent selective inhibitor of class II alpha PI3K (PI3K-C2α) with IC50 of 7 nM, six-fold selective over PI3K-C2β, 20-fold over PI3K-p110α. |
| PC-23003 |
MIPS-19416
PI3K inhibitor
|
MIPS-19416 is a potent dual class I and class II PI3Ks inhibitor with IC50 of 13 nM (PI3KC2α), equal to or more potent than against class I isoforms or against PI3KC2β (IC50=12-94 nM). |
| PC-23002 |
PITCOIN4
PI3KC2α inhibitor
|
PITCOIN4 is a potent, highly selective inhibitor of class II alpha PI3K (PI3K-C2α) with IC50 of 56 nM, >100-fold selectivity over PI3K-C2β. |
| PC-22536 |
TYM-3-98
PI3Kδ inhibitor
|
TYM-3-98 is a potent, selective inhibitor of PI3Kδ (PI3Kdelta) with IC50 of 7.1 nM, highly selective over other PI3K isoforms at both molecular and cellular levels. |
| PC-22488 |
Taselisib
PI3Kα inhibitor
|
Taselisib (GDC-0032) is a potent, selective inhibitor of PIK3CA (PI3Kα) with Ki of 0.29 nM and pAkt IC50 of 4 nM, 31-fold selective over PI3Kβ. |
| PC-22090 |
QR-7909
PI3Kα H1047R inhibitor
|
QR-7909 is a potent, specific and allosteric PI3Kα H1047R inhibitor with IC50 of 51 nM, 27-fold selective over WT PI3Kα in biochemical assays. |
