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Chemical Structure : PF-04979064
CAS No.: 1220699-06-8
Catalog No.: PC-42133Not For Human Use, Lab Use Only.
PF-04979064 is a highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-04979064 is a highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively.
PF-04979064 exhibits excellent in vitro potency, very good solubility, high LipE, excellent kinome selectivity, robust PK/PD correlation and TGI efficacy, and acceptable predicted human clearance after incorporating both CYP- and AO-mediated metabolism.
| M.Wt | 446.5016 | |
| Formula | C24H26N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 11 mg/mL |
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| Chemical Name/SMILES |
2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)- |
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1. Cheng H, et al. ACS Med Chem Lett. 2012 Nov 7;4(1):91-7.
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