| Cat. No. |
Product Name |
Information |
| PC-21408 |
NT160
class IIa HDAC inhibitor
|
NT160 is a high affinity, selective class-IIa histone deacetylase (HDAC) inhibitor with IC50 of 80 nM (HDAC4), 600-fold selectivity over HDAC2 and 27-fold selectivity over HDAC8. |
| PC-21407 |
YAK540
class IIa HDAC inhibitor
|
YAK540 is a potent, highly selective class IIa HDAC inhibitor with IC50 of 114 nM (HDAC4), displays excellent selectivity against HDAC2 (265-fold), HDAC6 (100-fold), and HDAC8 (82-fold). |
| PC-21115 |
HDAC3 inhibitor 4i
HDAC3 inhibitor
|
HDAC3 inhibitor 4i is a potent, selective HDAC3 inhibitor with IC50 of 14 nM, shows 121-fold selectivity over HDAC1 (IC50=1983 nM) and HDAC2 (IC50=1696 nM). |
| PC-20992 |
Yanostat
class I HDAC inhibitor
|
Yanostat (KH16) is a novel potent HDAC inhibitor with low nanomolar in vitro activity against class I HDACs (HDAC1/2/3 IC50=13/34/6 nM). |
| PC-20984 |
Citarinostat
HDAC6 inhibitor
|
Carinostat (ACY-241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with IC50 of 2.6 nM. |
| PC-20913 |
Givinostat hydrochloride monohydrate
pan HDAC inhibitor
|
Givinostat (ITF-2357) is a potent, orally active, pan-HDAC inhibitor with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. |
| PC-20784 |
Romidepsin
class I HDAC inhibitor
|
Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide) is a natrual produrct from Chromobacterium violaceum as class I HDACs inhibitor, inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1400 nM, respectively. |
| PC-20479 |
Purinostat
Class I /IIb HDAC inhibitor
|
Purinostat is a potent, highly selective class I and IIb HDAC inhibitor with IC50 of 0.81, 1.4, 1.7, and 3.8 nM for class I HDAC1, 2, 3, and 8, and 11.5, 1.1 nM for class IIb HDAC 6 and 10, respectively. |
| PC-20402 |
SBI-46
HDAC inhibitor
|
SBI-46 (SBI 46) is an antiandrogen-equipped histone deacetylase (HDAC) inhibitor, strongly binds to androgen receptor (AR, IC50=8.4 nM) and potently inhibited HDACs and the proliferation of AR+ CRPC. |
| PC-20239 |
HO53
HDAC3 inhibitor
|
HO53 is a small moecule inducer of cathelicidin antimicrobial peptide gene (CAMP) expression in bronchial epithelium cells, HO53 is a histone deacetylase (HDAC) inhibitor, interacts directly with HDAC3. |
| PC-20238 |
RGFP963
HDAC3 inhibitor
|
RGFP963 (RGFP 963) is a potent, selective class I HDAC inhibitor with IC50 of 1.51 uM, 0.75 and 0.096 uM for HDAC1, HDAC2, and HDAC3, respectively. |
| PC-20237 |
RGFP966
HDAC3 inhibitor
|
RGFP966 (RGFP 966) is a potent, specific HDAC3 inhibitor with IC50 of 0.08 uM, without effective inhibition of any other HDACs at 15 uM. |
