| Cat. No. |
Product Name |
Information |
| PC-26064 |
UVI5008
Epigenetic inhibitor
|
UVI5008 is a small molecule epigenetic modifier/modulator that inhibits histone deacetylases, sirtuins, and DNA methyltransferases, affects the death receptor (DR) pathway and reactive oxygen species (ROS) production in cancer cells. |
| PC-25935 |
Colrestat
class I HDAC inhibitor
|
Colrestat is a potent, selective inhibitor of class I histone deacetylases (HDACs) with IC50 of 41.2 nM, 52.5 nM and 74.3 nM for HDAC1, HDAC2 and HDAC3 respectively. |
| PC-25904 |
Mesinostat
HDAC6 inhibitor
|
Mesinostat is a potent and selective HDAC6 inhibitor with IC50 of 7.7 nM, >200-fold selective over HDAC1. |
| PC-25868 |
EKZ-438
HDAC6 inhibitor
|
EKZ-438 is a potent, selective, CNS-penetrant and orally bioavailable HDAC6 inhibitor with IC50 of 12 nM, >8,500-fold selectivity for HDAC6 versus all other HDAC6 paralogs. |
| PC-25412 |
SYSUP007
HDAC inhibitor
|
SYSUP007 is a derivative of the FTO inhibitor rhein, and HDAC and SGK1 inhibitor, inhibits the proliferation of human GBM cells. |
| PC-25166 |
DAC-001
HDAC1 activator
|
DAC-001 is a small molecule, cell-active activator of HDAC1, exhibits dose-dependent activation of HDAC1 in vitro in a microfluidics-based assay at 5-10 uM, displayes significant protection against DNA breaks. |
| PC-25165 |
DAC-003
HDAC1 activator
|
DAC-003 is a small molecule activator of HDAC1, exhibits dose-dependent activation of HDAC1 in vitro in a microfluidics-based assay at 5-10 uM, DAC-003 is protective against oxidative stress. |
| PC-25161 |
CBUD-1001
HDAC1 inhibitor
|
CBUD-1001 is specific small molecule HDAC1 inhibitor with IC50 of 28.1 nM, inhibits HDAC2 and HDAC3 with IC50 values of 158 nM and 404 nM, respectively. |
| PC-25122 |
Dual Hsp90-HDAC6 inhibitor 17
Hsp90/HDAC6 inhibitor
|
Dual Hsp90/HDAC6 inhibitor 17 is a potent, selective dual Hsp90/HDAC6 inhibitor with IC50 of 28/96 nM respectively. |
| PC-25111 |
Martinostat hydrochloride
HDAC inhibitor
|
Martinostat hydrochloride is a potent, selective inhibitor for class I and class-IIb HDACs with IC50 of 0.3/2.0/0.6 nM for HDAC1/2/3 and 4.1 nM for HDAC6 respectively, >100-fold selectivity over other HDAC isoforms. |
| PC-24898 |
TNI-97
HDAC6 inhibitor
|
TNI-97 is a potent, highly selective and orally bioavailable HDAC6 inhibitor with IC50 of 0.2 nM. |
| PC-24776 |
ITF3107
HDAC6 inhibitor
|
ITF3107 is a potent, selective HDAC6 inhibitor with IC50 of 5 nM, >70-fold more selective for HDAC6over HDAC1/2/3. |
