| Cat. No. |
Product Name |
Information |
| PC-23970 |
RG2833
HDAC1/3 inhibitor
|
RG2833 is a potent, orally bioavailable, brain-penetrant histone deacetylase HDAC1/3 inhibitor with IC50 of 60/50 mM respectively. |
| PC-23965 |
HDAC3 inhibitor LSQ-28
HDAC3 inhibitor
|
LSQ-28 is a potent, selective HDAC3 inhibitor with IC50 of 42 nM, >150-fold selective over HDAC1, HDAC2, and HDAC6. |
| PC-23806 |
NSC3852
HDAC inhibitor
|
NSC3852 is a small molecule inhibitor of histone deacetylase (HDAC) with cell differentiation and antiproliferative activity in human breast cancer cells, synergistically enhances the cytotoxicity of olaparib in oral squamous cell carcinoma. |
| PC-23423 |
HDAC6 inhibitor OXHA
HDAC6 inhibitor
|
OXHA is a potent selective HDAC6 inhibitor with IC50 of 3.7 nM, promotes the acetylation of α-tubulin, >40-fold selectivity over HDAC1/2/3/8. |
| PC-23348 |
PB131
HDAC6 inhibitor
|
PB131 is a potent, selective and brain-permeable HDAC6 inhibitor with IC50 of 1.8 nM, <100-fold selective over other HDAC isoforms. |
| PC-22845 |
HQ-30
HDAC3 inhibitor, PD-L1 degrader
|
HQ-30 is a potent, dual-acting HDAC3 inhibitor (IC50=89 nM) and PD-L1 degrader (DC50=5.7 uM, Dmax=80% at 10 uM). |
| PC-22782 |
Leuxinostat
HDAC6 inhibitor
|
Leuxinostat is a potent, specific HDAC6 inhibitor with IC50 of 30 nM, induces apoptosis in FLT3-ITD AML cells. |
| PC-22672 |
SP-1-303
HDAC inhibitor, ATM activator
|
SP-1-303 is a dual-targeting class I HDAC inhibitor and ATM activator with IC50 of 12/14 nM for HDAC1/3, preferentially inhibits ER+ breast cancer growth. |
| PC-22549 |
NT376
class IIa HDAC inhibitor
|
NT376 is a highly potent, selective class-IIa HDACs inhibitor with cellular IC50 of 32 nM in HT-29 cell line, >100-fold selectivity over other HDAC classes. |
| PC-22482 |
Bufexamac
HDAC6/10 inhibitor
|
Bufexamac (Bufexamic acid) is a selective class IIb (HDAC6, HDAC10) HDAC inhibitor with Kd of 0.53 µM and 0.22 µM respectively, also is a nonsteroida anti-inflammatory agent targeting LTA4H. |
| PC-22427 |
PCI-34051
HDAC8 inhibitor
|
PCI-34051 is a potent, specific HDAC8 inhibitor with IC50 of 10 nM, >200-fold selectivity over other HDAC isoforms. |
| PC-22259 |
QAPHA
Tubulin/HDAC6 inhibitor
|
QAPHA is a dual function small molecule as both a tubulin polymerization and HDAC inhibitor, induces immunogenic cell death (ICD) through HDAC6 inhibition. |
