Catalog No.: PC-28355Not For Human Use, Lab Use Only.
SBHA (Suberoyl bis-hydroxamic acid) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively, renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways.
SBHA (Suberoyl bis-hydroxamic acid) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively, renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways, induces accumulation of hyperacetylated histone H4 in cultured cells.
Physicochemical Properties
M.Wt
204.23
Formula
C8H16N2O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N1,N8-Dihydroxyoctanediamide
References
1. Brinkmann H, et al. J Biol Chem. 2001 Jun 22;276(25):22491-9.
2. Jiri Neuzil, et al. Biochem Biophys Res Commun. 2004 Jan 30;314(1):186-91.
3. V M Richon, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7.
