| Cat. No. |
Product Name |
Information |
| PC-21402 |
Birinapant
IAP inhibitor
|
Birinapant (TL32711) is a bivalent, selective small molecule SMAC mimetic, binds with high affinity to multiple members of the IAP family with Kd of 45 nM and <1 nM for XIAP and cIAP1 respectively. |
| PC-20998 |
LCL161
IAP inhibitor
|
LCL161 is a monovalent Smac-mimetic, binds IAPs with high affinity and initiates the destruction of cIAP1 and cIAP2 (encoded by BIRC2 and BIRC3, respectively) and prevention of caspase inhibition by XIAP. |
| PC-20879 |
142D6
IAP inhibitor
|
142D6 is a potent, Lys-covalent pan-IAP inhibitor, targets the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family with IC50 of 43/21/21 nM for XIAP/cIAP1/cIAP2, respectively. |
| PC-20236 |
RMT 5265
IAP inhibitor
|
RMT 5265 (RMT5265) is a potent, small molecule bivalent mimic of Smac, inhibits XIAP and cIAP1/2 through the BIR3 domain. |
| PC-47055 |
ARTS mimetic A4
ARTS mimetic
|
ARTS mimetic A4 is a small molecule that mimics the function of the pro-apoptotic ARTS (Sept4_i2) protein, binds the ARTS pocket in XIAP-BIR3, but not cIAP1, specifically promotes degradation of XIAP and induces caspase-mediated cell death. |
| PC-72363 |
SW IV-134
SMAC drug conjugate
|
SW IV-134 is a sigma-2/SMAC drug conjugate, chemically linked the sigma-2 ligand SW43 to the Smac mimetic SW IV-52, induces degradation of cIAP-1 and cIAP-2. |
| PC-72362 |
SW IV-52
XIAP inhibitor
|
SW IV-52 is a pro-apoptotic small molecule SMAC mimetic and XIAP-inhibitor. |
| PC-35889 |
Xevinapant
IAP inhibitor
|
Xevinapant (DEBIO 1143, AT-406, SM406, ARRY-334543, D1143) is a potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively. |
| PC-35081 |
MX107
Survivin inhibitor
|
MX107 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 3.1 uM. |
| PC-35080 |
MX106
Survivin inhibitor
|
MX106 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 2.2 uM. |
| PC-63393 |
ASTX660 mesylate
IAP inhibitor
|
ASTX660 mesylate is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM. |
| PC-63392 |
ASTX660 hydrochloride
IAP inhibitor
|
Tolinapant (ASTX660) hydrochloride is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM. |
