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ARTS mimetic A4

Chemical Structure : ARTS mimetic A4

CAS No.: 375835-04-4

ARTS mimetic A4

Catalog No.: PC-47055Not For Human Use, Lab Use Only.

ARTS mimetic A4 is a small molecule that mimics the function of the pro-apoptotic ARTS (Sept4_i2) protein, binds the ARTS pocket in XIAP-BIR3, but not cIAP1, specifically promotes degradation of XIAP and induces caspase-mediated cell death.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ARTS mimetic A4 is a small molecule that mimics the function of the pro-apoptotic ARTS (Sept4_i2) protein, binds the ARTS pocket in XIAP-BIR3, but not cIAP1, specifically promotes degradation of XIAP and induces caspase-mediated cell death.
    A4 binds to a distinct ARTS binding pocket in the XIAP-BIR3 (baculoviral IAP repeat 3) domain with Kd of 348 nM.
    A4 stimulated poly-ubiquitylation and UPS-mediated degradation of XIAP and Bcl-2, but not cIAP1.
    ARTS-mimetic A4 is a potent inducer of caspase-9- and caspase-3-mediated apoptotic cell death.

    Physicochemical Properties

    M.Wt 440.928
    Formula C23H25ClN4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    methyl 3-(2-(4-benzylpiperazin-1-yl)acetamido)-5-chloro-1H-indole-2-carboxylate

    References

    1. Dana Mamriev, et al. Cell Death Dis. 2020 Jun 25;11(6):483.

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