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Cat. No. Product Name Information
PC-20625

Imirestat

Aldose reductase inhibitor

Imirestat (AL-1576) is a potent aldose reductase inhibitor with IC50 of 8.5 nM for rat lens aldose reductase, with similar IC50 value for the human placental enzyme, shows high affinity for AKR1A1 and AKR1B1 with Ki of 47 and 46 nM respectively.
PC-20086

BAY1128688

AKR1C3 inhibitor

BAY1128688 is a potent, selective steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 1.4 nM (human AKR1C3).
PC-38679

Govorestat

Aldose Reductase inhibitor

Govorestat (AT-007) is a potent, selective, CNS-penetrant aldose reductase (aldehyde reductase) inhibitor with IC50 of 0.1 nM, reduces toxic galactitol levels and prevents galactosemia disease complications in vivo.
PC-72285

TH-3021

AKR1C3 inhibitor

TH-3021 (SN336384) is a potent and specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3) with IC50 of 110 nM in isolated enzyme assays and 18 nM in cellular assays, displays no inhibitory action against AKR1C1/1C2/1C4 (IC50>30 uM).
PC-35291

AKR1C3 inhibitor KV-37

AKR1C3 inhibitor

AKR1C3 inhibitor KV-37 is a potent, isoform selective and metabolically stable inhibitor of Aldo-keto reductase 1C3 (AKR1C3) with IC50 of 66 nM, displays 109-fold selectivity over AKR1C2.
PC-62883

MK204

AKR1B10 inhibitor

MK204 is a potent, selective AKR1B10 inhibitor with IC50 of 80 nM, shows high selective (270-fold) over AKR1B1.
PC-62882

IDD388

Aldose reductase inhibitor

IDD388 is a potent aldose reductase (ALR2 or AKR1B1) inhibitor with IC50 of 0.4 uM, shows weak inhibition for AKR1B10 (IC50=4.4 uM).
PC-61992

Fidarestat

Aldose reductase inhibitor

Fidarestat (SNK860) is a potent, selective aldose reductase inhibitor with IC50 of 26 nM.
PC-60998

ASP9521

AKR1C3

ASP9521(ASP-9521) is a potent, selective, orally bioavailable inhibitor of Aldo-keto reductase 1C3 (17βHSD5, AKR1C3) with IC50 of 11 nM and 49 nM for recombinant human or cynomolgus monkey AKR1C3, respectively.
PC-45580

Caficrestat

Aldose reductase inhibitor

AT-001 (Caficrestat) is a highly potent, selective inhibitor of aldose reductase enzymatic activity with IC50 of 28.9 pM.
PC-45922

Epalrestat

Aldose reductase inhibitor

Epalrestat (ONO-2235) is a noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively.
PC-23116

pyrone-211

AKR1C3 inhibitor, GPR84 agonist

pyrone-211 is a potent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), also is a potent agonist of the semi-orphan receptor GPR84.

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