Catalog No.: PC-24206Not For Human Use, Lab Use Only.
Pan-AKR1C inhibitor 29 is a potent, pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor with IC50 of 0.09 μM, 0.28 μM, 0.05 μM, 0.51 μM for AKR1C1, AKR1C2, AKR1C3, and AKR1C4 respectively.
Pan-AKR1C inhibitor 29 is a potent, pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor with IC50 of 0.09 μM, 0.28 μM, 0.05 μM, 0.51 μM for AKR1C1, AKR1C2, AKR1C3, and AKR1C4 respectively.
Pan-AKR1C inhibitor 29 significantly induced the anti-proliferative effect of DOX on MCF-7/ADR.
Pan-AKR1C inhibitor 29 exhibited synergistic effects, as evidenced by the calculated CI values (0.221–0.524) within the synergistic range for MCF-7/ADR cells, when combined with DOX.
The combination of 29 with DOX effectively suppressed cell proliferation and reversed DOX resistance.
Pan-AKR1C inhibitor 29 can enhance DOX-induced DNA damage, thereby inducing apoptosis and ultimately reversing DOX-resistance.
Pan-AKR1C inhibitor 29 significantly sensitized DOX-resistance cancer cells to DOX on MCF-7/ADR xenograft models.
