Cat. No. |
Product Name |
Information |
PC-72457 |
Azoffluxin
Cdr1 inhibitor
|
Azoffluxin (CMLD012336) is a bis-benzodioxolylindolinone that synergizes with fluconazole against C. auris through the inhibition of efflux pump Cdr1, thus increasing intracellular fluconazole levels. |
PC-63228 |
ML316
Mir1 inhibitor
|
ML316 is a specific antifungal agent that fungal-selectively inhibits the mitochondrial phosphate carrier Mir1, exhibits potent antifungal activity against the moderatelyazole-resistant C. albicans strain CaCi-2 with MIC of 0.05 ug/ml. |
PC-63050 |
Butenafine hydrochloride
|
Butenafine is a synthetic benzylamine antifungal that inhibits the synthesis of ergosterol by inhibiting squalene epoxidase. |
PC-62617 |
APX001
|
APX001 (Fosmanogepix, E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris). |
PC-62615 |
PC945
|
Opelconazole (PC945) is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively. |
PC-61753 |
VT-1161
Fungal CYP51 inhibitor
|
VT-1161 (Oteseconazole) is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM. |
PC-61752 |
VT-1598
Fungal CYP51B inhibitor
|
VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM. |
PC-70224 |
F-901318
Fungal DHODH inhibitor
|
F-901318 (Olorofim) is a novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM. |
PC-60411 |
SCY-078
|
Ibrexafungerp (MK 3118, SCY-078) is a novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml). |
PC-45366 |
Micafungin
|
Micafungin is an echinocandin antifungal drug which can inhibit 1,3-beta-D-glucan synthase, inhibits the production of 1,3-β-D-glucan in fungal cell walls, acts as a neddylation inhibitor that targets Ubiquitin-conjugating enzyme 2M (UBE2M). |
PC-42761 |
AN-2690
LeuRS inhibitor
|
AN-2690 (Tavaborole) is an antifungal compound that inhibits cytoplasmic leucyl-tRNA synthetase (LeuRS) for the potential treatment of nnychomycosis. |
PC-45319 |
Itraconazole
Hedgehog inhibitor, C1GALT1 inhibitor
|
Itraconazole (R51211) is a triazole antifungal agent for fungal infections via inhibition of lanosterol 14α-demethylase, inhibits hedgehog signaling pathway with IC50 of 800 nM. |