Erg6 inhibitor H55

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Chemical Structure : Erg6 inhibitor H55

Catalog No.: PC-20789Not For Human Use, Lab Use Only.

Erg6 inhibitor H55 is an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase (Erg6), potently inhibits C. albicans hyphal formation in multiple cultural conditions.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Erg6 inhibitor H55 is an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase (Erg6), potently inhibits C. albicans hyphal formation in multiple cultural conditions.
H55 monotherapy exhibits therapeutic efficacy in mouse models of azole-resistant candidiasis.
H55 treatment increases the accumulation of zymosterol, the substrate of C-24 sterol methyltransferase (Erg6).

Physicochemical Properties

M.Wt	517.45
Formula	C26H21BrN4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-(4-(4-bromophenyl)-2-(phenylimino)thiazol-3(2H)-yl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

References

1. Jin X, et al. Cell Chem Biol. 2023 May 2:S2451-9456(23)00116-2.

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