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Request The Product List ofCheckpoint Kinase (Chk) Checkpoint Kinase (Chk)

Cat. No. Product Name Information
PC-35362

BAY-524

BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.
PC-43443

CHIR-124

CHIR-124 is a potent, selective Chk1 inhibitor with in vitro IC50 of 0.3 nM, 2,000-fold selectivity over Chk2.
PC-63128

BAY-1816032

BAY-1816032 (BAY1816032) is a highly potent, selective, orally active BUB1 mitotic checkpoint serine/threonine kinase with IC50 of 7 nM, displays excellent selectivity on a panel of 395 kinases.
PC-60310

GNE-900

GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM.
PC-60285

XL-844

XL-844 (EXEL9844) is a potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.
PC-60276

GDC-0575

GDC-0575 (ARRY-575, RG-7741) is a potent, selective and orally bioavailable Chk1 inhibitor with IC50 of 1.2 nM.
PC-45427

Prexasertib

Prexasertib (LY-2606368) is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.

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