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Chemical Structure : MU 380
Catalog No.: PC-60583Not For Human Use, Lab Use Only.
MU 380 is a novel potent, selective CHK1 inhibitor with IC50 of 2 nM, >80-fold selectivity over CHK2.
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MU 380 is a novel potent, selective CHK1 inhibitor with IC50 of 2 nM, >80-fold selectivity over CHK2.
MU 380 sensitizes a variety of tumor cell lines to hydroxyurea or gemcitabine up to 10 times.
MU 380 shows extended inhibitory effects in cells, and unlike SCH900776, does not undergo in vivo N-dealkylation to the significantly less selective metabolite.
MU 380 causes higher accumulation of DNA damage in tumor cells and subsequent enhanced cell death, and is more efficacious in the A2780 xenograft mouse model.
| M.Wt | 430.233 | |
| Formula | C15H15BrF3N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Samadder P, et al. Mol Cancer Ther. 2017 Sep;16(9):1831-1842.
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