| Cat. No. |
Product Name |
Information |
| PC-20966 |
icFSP1
FSP1 inhibitor
|
icFSP1 is a potent, selective human ferroptosis suppressor protein-1 (hFSP1) inhibitor, promotes ferroptosis and indirectly inhibits FSP1 by inducing condensate formation. |
| PC-20267 |
GPX4 inhibitor 24
GPX4 inhibitor
|
GPX4 inhibitor 24 is a potent glutathione peroxidase 4 (GPX4) inhibitor, induces ferroptosis in vivo. |
| PC-49555 |
YL-939
Ferroptosis inhibitor
|
YL-939 is a novel non-classical and specific ferroptosis inhibitor, targets and binds directly to the prohibitin 2 (PHB2) protein with Kd of 3.43 uM in SPR assays. |
| PC-49542 |
LOC1886
GPX4 inhibitor
|
LOC1886 is a small molecule allosteric inhibitor of GPX4, inhibits enzymatic activity of GPX4 in HT1080 cell lysates with Ki of 102 uM, degrades GPX4 to induce ferroptosis, binds covalently to C66 of GPX4. |
| PC-38437 |
iFSP1
FSP1 inhibitor
|
iFSP1 (FSP1 inhibitor) is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1, AIFM2) with IC50 of 103 nM. |
| PC-73336 |
iHPCAL1
HPCAL1 inhibitor
|
iHPCAL1 is a ferroptosis inhibitor that effectively inhibits RSL3-induced cell death, directly interacts with HPCAL1 and significantly inhibits HPCAL1 protein expression at 1.25-5 uM in HT-1080 and Calu-1 cells. |
| PC-72763 |
NPD4928
FSP1 inhibitor
|
NPD4928 (NPD 4928) is a small molecule that enhances ferroptosis via inhibition of ferroptosis suppressor protein 1 (FSP1). |
| PC-72335 |
Ironomycin
Ferroptosis inducer
|
Ironomycin (Ironomycin AM5) is a lysosomal iron-targeting small molecule that reduces the mitochondrial iron load, resulting in the potent disruption of mitochondrial metabolism. |
| PC-36116 |
Imidazole ketone erastin
Ferroptosis inducer
|
Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications. |
| PC-35991 |
SRS11-92
Ferroptosis inhibitor
|
SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM. |
| PC-35744 |
Ferrostatin-1
Ferroptosis inhibitor
|
Ferrostatin-1 is a potent ferroptosis inhibitor with IC50 of 33 nM, inhibits erastin-induced ferroptosis in HT-1080 cells with EC50 of 60 nM. |
| PC-35743 |
UAMC-3203
Ferroptosis inhibitor
|
UAMC-3203 is a novel potent, drug-like ferroptosis inhibitor with IC50 of 12 nM, inhibit erastin-induced ferroptotic cell death more potently than Ferrostatin-1. |
