GPX4 inhibitor 24

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Chemical Structure : GPX4 inhibitor 24

Catalog No.: PC-20267Not For Human Use, Lab Use Only.

GPX4 inhibitor 24 is a potent glutathione peroxidase 4 (GPX4) inhibitor, induces ferroptosis in vivo.

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Biological Activity

GPX4 inhibitor 24 is a potent glutathione peroxidase 4 (GPX4) inhibitor with cell viability EC50 of 117 nM in HT1080 (GPX4 dependent) cell, induces ferroptosis.
GPX4 inhibitor 24 (100 and 200 mg/kg) engages kidney GPX4 and induces PD markers in Scid/beige mice.
GPX4 inhibitor 24 is a potentially useful tool compound for in vivo POC studies.

Physicochemical Properties

M.Wt	460.93
Formula	C22H21ClN2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-(methylsulfonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

References

1. Randolph JT, et al. J Med Chem. 2023 Mar 6. doi: 10.1021/acs.jmedchem.2c01415.

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