| Cat. No. |
Product Name |
Information |
| PC-21694 |
YQ128
NLRP3 inhibitor
|
YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM. |
| PC-21637 |
ZYIL1
NLRP3 inhibitor
|
ZYIL1 (Usnoflast) is a potent, orally active, selective NLRP3 inflammasome inhibitor, Nigericin-mediated interleukin (IL)-1β release in isolated microglia cells with IC50 of 43 nM. |
| PC-21283 |
NT-0796
NLRP3 inhibitor
|
NT-0796 is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM. |
| PC-20956 |
ADS032
Inflammasome inhibitor
|
ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin‐induced NLRP3‐induced IL‐1β secretion from LPS‐primed iBMDMs with IC50 of 30 uM. |
| PC-20303 |
JC124
NLRP3 inhibitor
|
JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells. |
| PC-20225 |
JC2-11
Inflammasome inhibitor
|
JC2-11 is an anti-inflammasome compound and a pan-inhibitor of the NLRP3, NLRC4, and AIM2 inflammasomes. |
| PC-49808 |
FK 565
NOD1 agonist
|
FK565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| PC-49463 |
NIC7
NLRP3 inhibitor
|
NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase. |
| PC-49396 |
GDC-2394
NLRP3 inhibitor
|
GDC-2394 (GDC2394) is a potent and selective NLRP3 inhibitor with IC50 of 5.4 nM (IL-1β inhibition in PBMCs). |
| PC-49268 |
NDT-30805
NLRP3 inhibitor
|
NDT-30805 is a potent and selective small molecule NLRP3 inflammasome inhibitor with IC50 of 13 nM for IL-1β inhibition in PBMCs. |
| PC-38558 |
GSK669
NOD2 inhibitor
|
GSK669 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling (IC50=0.5 uM), has an IC50 of 3.2 uM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
| PC-38557 |
GSK717
NOD2 inhibitor
|
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, has an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
