| Cat. No. |
Product Name |
Information |
| PC-35078 |
Oridonin
NLRP3 inhibitor, β-arrestin inhibitor, AKT inhibitor
|
Oridonin (NSC 250682, Isodonol, β-arrestin inhibitor Cmpd-5) is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK. |
| PC-63450 |
NBC19
NLRP3 inhibitor
|
NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.. |
| PC-43229 |
MCC950 sodium
NLRP3 inhibitor
|
MCC950 (CP456773, CRID3) sodium is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively. |
| PC-43228 |
MCC950
NLRP3 inhibitor
|
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3. |
| PC-61787 |
JC-171
NLRP3 inhibitor
|
JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM. |
| PC-42228 |
NOD-IN-1
NOD1/NOD2 inhibitor
|
NOD-IN-1 is a potent, dual inhibitor of NOD1 and NOD2 with IC50 of 5.74 uM and 6.45 uM, respectively. |
| PC-45499 |
Nodinitib-1
NOD1 inhibitor
|
Nodinitib-1 (ML130, Noditinib 1) is a potent and selective NOD1 inhibitor with IC50 of 0.56 uM. |
| PC-28305 |
Stavudine
NLRP3 inflammasome inhibitor, NRTI
|
Stavudine (d4T) is a nucleoside reverse transcriptase inhibitor (NRTI), inhibits HIV-1 reverse transcriptase, also blocks NLRP3 inflammasome activation. |
| PC-28304 |
Kamuvudine-9
NLRP3 inflammasome inhibitor
|
Kamuvudine-9 (K-9) is a derivative of nucleoside reverse transcriptase inhibitor (NRTI) that inhibits inflammasome activation, disrupts interactions between NLRP3 and NIMA-related kinase 7 (NEK7) and between NLRP3 and NLR CARD domain containing 4 (NLRC4). |
| PC-27694 |
VVD-338213
NLRP3 inhibitor
|
VVD-338213 is a potent, brain-penetrant, covalent NLRP3 inhibitor with IC50 of 89 nM for inhibiton of IL-1β secretion from human PBMCs, inhibits IL-1β release via preventing inflammasome formation. |
| PC-27509 |
Trabzanoflast
NLRP3 inhibitor
|
Trabzanoflast is a potent, selective NLRP3 inflammasome inhibitor. |
| PC-27416 |
Clasornoflast
NLRP3 inhibitor
|
Clasornoflast is a potent, selective NLRP3 inflammasome inhibitor. |
