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NDT-19795

Chemical Structure : NDT-19795

CAS No.: 2272917-12-9

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NDT-19795 (NDT19795)

Catalog No.: PC-21813Not For Human Use, Lab Use Only.

NDT-19795 is the carboxylic acid metabolite of selective NLRP3 inhibitor NT-0796, suppresses release of IL-1β in LPS-activated human PBMCs with IC50 of 47 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NDT-19795 is the carboxylic acid metabolite of selective NLRP3 inhibitor NT-0796, suppresses release of IL-1β in LPS-activated human PBMCs with IC50 of 47 nM.
NDT-19795 inhibits speck formation concentration-dependently with IC50 of 0.46 uM.
NDT-19795 inhibits IL-1β output from human PBMCs stimulated with LPS and ATP.
NDT-19795 also inhibits IL-18 output from LPS/ATP-treated PBMCs with IC50 of 57 nM.

Physicochemical Properties

M.Wt 367.41
Formula C20H21N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)oxy)-3-(pyrimidin-2-yl)propanoic acid

References

1. Harrison D, et al. J Med Chem. 2023 Nov 9;66(21):14897-14911.

2. Smolak P, et al. J Pharmacol Exp Ther. 2024 Feb 15;388(3):798-812.

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