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Cat. No. Product Name Information
PC-49338

EVT-201

GABAA PAM

EVT-201 (Dimdazenil, EVT 201) is a partial positive allosteric GABA(A) receptor modulator with potential for the treatment of insomnia.
PC-47098

ASP8062

GABAB PAM

ASP8062 is a potent, selective GABA B receptor positive allosteric modulator (PAM), positive allosteric modulating activity for human and rat GABAB receptors, exerts analgesic effects in rat model of fibromyalgia.
PC-38727

SGS742

GABAB antagonist

CGP 36742 (SGS-742) is a BBB-penetrant GABAB receptor antagonist, discretely up-regulates GABAB receptor binding sites.
PC-38491

Imidazenil

GABAA modulator

Imidazenil is a partial allosteric modulator of gamma-aminobutyric acid type A receptor (GABAA receptor) with anxiolytic and anticonvulsant effects, inhibits [3H] flumazenil binding to mouse cerebral cortical membranes in vitro with IC50 of 0.9 nM.
PC-38382

Alogabat

GABAA α5 PAM

Alogabat (RG7816, RO 7017773) is a GABAA α5 receptor positive allosteric modulator (PAM).
PC-73410

Cipepofol

GABA potentiator

Cipepofol (HSK3486) is a small molecule γ-aminobutyric acid (GABA) receptor potentiator and new sedative-hypnotic agent and a promising intravenous anaesthetic candidate.
PC-38319

Zuranolone

GABAA receptor modulator

Zuranolone (SAGE-217) is an orally active, positive allosteric modulator of the GABAA receptor with EC50 of 375/299 nM (α1β2γ2/α4β3δ).
PC-35484

HZ-166

GABAA α2/α3 PAM

HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors.
PC-35483

KRM-II-81

GABAA α2/α3 PAM

KRM-II-81 is a selective α2/α3 subtype GABAA receptor ligand (positive allosteric modulator) with EC50 of 937 nM for α3β3γ2 GABAAR.
PC-35454

GR3027

GABAA antagonist

GR3027 (Golexanolone) is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC.
PC-63442

ONO-8590580

GABAA α5 PAM

ONO-8590580 is a novel potent, selective GABAA α5 negative allosteric modulator, binds to the benzodiazepine binding sites on recombinant human α5-containing GABAA receptors with Ki of 7.9 nM.
PC-63310

MIDD0301

α5β3γ2 GABAA inhibitor

MIDD0301 is a potent, positive allosteric, α5β3γ2 selective, GABAA receptor (GABAAR) ligand with EC50 of 17 nM, shows no significant binding at the peripheral GABAAR at 10 uM.

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