| Cat. No. |
Product Name |
Information |
| PC-25648 |
TPA023B
α2/α3 GABAAR agonist
|
TPA023B (TPA-023B) is selective partial agonist / positive allosteric modulat of GABAA receptor α2/α3 subtype with Ki of 0.73 nM/2 nM respectively, also is an α1 subtype antagonist with Ki of 1.8 nM. |
| PC-23986 |
Muscimol
GABA agonist, NINJ1 inhibitor
|
Muscimol (Agarin) is a psychoactive isoxazole and selective neurotransmitter GABA agonist, binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with EC50 of 200 nM, also is a small molecule inhibitor of ninjurin-1 (NINJ1) oligomerization and NINJ1 mediated membrane rupture. |
| PC-22875 |
DDL-920
GABAA receptor NAM
|
DDL-920 is a potent, selective and brain permeable negative allosteric modulator (NAM) of the γ-aminobutyric acid type A receptors (GABARs), inhibits parvalbumin (PV) expressing interneurons (PV+INs) and consequently enhances γ-oscillations both in vitro and in vivo. |
| PC-49338 |
EVT-201
GABAA PAM
|
EVT-201 (Dimdazenil, EVT 201) is a partial positive allosteric GABA(A) receptor modulator with potential for the treatment of insomnia. |
| PC-47098 |
ASP8062
GABAB PAM
|
ASP8062 is a potent, selective GABA B receptor positive allosteric modulator (PAM), positive allosteric modulating activity for human and rat GABAB receptors, exerts analgesic effects in rat model of fibromyalgia. |
| PC-38727 |
SGS742
GABAB antagonist
|
CGP 36742 (SGS-742) is a BBB-penetrant GABAB receptor antagonist, discretely up-regulates GABAB receptor binding sites. |
| PC-38491 |
Imidazenil
GABAA modulator
|
Imidazenil is a partial allosteric modulator of gamma-aminobutyric acid type A receptor (GABAA receptor) with anxiolytic and anticonvulsant effects, inhibits [3H] flumazenil binding to mouse cerebral cortical membranes in vitro with IC50 of 0.9 nM. |
| PC-38382 |
Alogabat
GABAA α5 PAM
|
Alogabat (RG7816, RO7017773) is a potent, selective GABAA-α5 receptors positive allosteric modulator (PAM) with Ki of 7.9 nM for GABAA-α5β3γ2 receptors in rats, 37-, 26-, and 18-fold selectivity over GABAA α1β3γ2, α2β3γ2, and α3β3γ2, respectively. |
| PC-73410 |
Cipepofol
GABA potentiator
|
Cipepofol (HSK3486) is a small molecule γ-aminobutyric acid (GABA) receptor potentiator and new sedative-hypnotic agent and a promising intravenous anaesthetic candidate. |
| PC-73213 |
CGP52432
GABAB antagonist
|
CGP52432 is a potent, selective GABAB receptor antagonist with IC50 of 85 nM. |
| PC-38319 |
Zuranolone
GABAA receptor modulator
|
Zuranolone (SAGE-217) is an orally active, positive allosteric modulator of the GABAA receptor with EC50 of 375/299 nM (α1β2γ2/α4β3δ). |
| PC-35484 |
HZ-166
GABAA α2/α3 PAM
|
HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors. |
