Chemical Structure : DDL-920
CAS No.:
1236105-84-2
DDL-920
(DDL920)
Catalog No.: PC-22875Not For Human Use, Lab Use Only.
DDL-920 is a potent, selective and brain permeable negative allosteric modulator (NAM) of the γ-aminobutyric acid type A receptors (GABARs), inhibits parvalbumin (PV) expressing interneurons (PV+INs) and consequently enhances γ-oscillations both in vitro and in vivo.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DDL-920 is a potent, selective and brain permeable negative allosteric modulator (NAM) of the γ-aminobutyric acid type A receptors (GABAARs), inhibits parvalbumin (PV) expressing interneurons (PV+INs) and consequently enhances γ-oscillations both in vitro and in vivo.
DDL-920 ( 1 nM) increases the power of the γ-oscillations, blocks >75% of tonic inhibition of PV+INs with only a negligible effect on their phasic inhibition in vitro.
DDL-920 increases γ-oscillations and improves cognition/memory in a mouse model of Alzheimer's disease (AD).
DDL-920 (10 mg/kg, oral) restored the cognitive/memory impairments of 3- to 4-mo-old AD model mice as measured by their performance in the Barnes maze.
Physicochemical Properties
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M.Wt
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307.40
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Formula
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C19H21N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(naphthalen-2-ylmethyl)-4-(piperidin-4-yl)-1H-pyrazol-1-ol
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References
1. Wei X, et al. Proc Natl Acad Sci U S A. 2024 Aug 13;121(33):e2400420121.
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