Catalog No.: PC-22875Not For Human Use, Lab Use Only.
DDL-920 is a potent, selective and brain permeable negative allosteric modulator (NAM) of the γ-aminobutyric acid type A receptors (GABARs), inhibits parvalbumin (PV) expressing interneurons (PV+INs) and consequently enhances γ-oscillations both in vitro and in vivo.
DDL-920 is a potent, selective and brain permeable negative allosteric modulator (NAM) of the γ-aminobutyric acid type A receptors (GABAARs), inhibits parvalbumin (PV) expressing interneurons (PV+INs) and consequently enhances γ-oscillations both in vitro and in vivo.
DDL-920 ( 1 nM) increases the power of the γ-oscillations, blocks >75% of tonic inhibition of PV+INs with only a negligible effect on their phasic inhibition in vitro.
DDL-920 increases γ-oscillations and improves cognition/memory in a mouse model of Alzheimer's disease (AD).
DDL-920 (10 mg/kg, oral) restored the cognitive/memory impairments of 3- to 4-mo-old AD model mice as measured by their performance in the Barnes maze.
