| Cat. No. |
Product Name |
Information |
| PC-47098 |
ASP8062
GABAB PAM
|
ASP8062 is a potent, selective GABA B receptor positive allosteric modulator (PAM), positive allosteric modulating activity for human and rat GABAB receptors, exerts analgesic effects in rat model of fibromyalgia. |
| PC-38319 |
Zuranolone
GABAA receptor modulator
|
Zuranolone (SAGE-217) is an orally active, positive allosteric modulator of the GABAA receptor with EC50 of 375/299 nM (α1β2γ2/α4β3δ). |
| PC-35483 |
KRM-II-81
|
KRM-II-81 is a selective α2/α3 subtype GABAA receptor ligand (positive allosteric modulator) with EC50 of 937 nM for α3β3γ2 GABAAR. |
| PC-63442 |
ONO-8590580
GABAA α5 PAM
|
ONO-8590580 is a novel potent, selective GABAA α5 negative allosteric modulator, binds to the benzodiazepine binding sites on recombinant human α5-containing GABAA receptors with Ki of 7.9 nM. |
| PC-62771 |
TP003
GABAA α3 agonist
|
TP003 is a potent, functional selectivity for α3 subunit-containing GABAA receptor agonist with Ki of <1 nM for α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2, has no affinity for α4β3γ2 and α6β3γ2 (Ki>1 uM). |
| PC-62770 |
MRK-623
GABAA α2/α3 agonist
|
MRK-623 is a potent, α2/α3 subunit functionally selectivie GABAA receptor agonist with Ki values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for α1, α2, α3, and α5, respectively. |
| PC-62768 |
TPA023B
GABAA α2/α3 agonist
|
TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype. |
| PC-62098 |
LAU159
|
LAU159 is a potent, functionally selective positive modulator of α6β3γ2 GABAA receptor.. |
| PC-62089 |
PF-06372865
|
PF-06372865 (Darigabat) is a novel potent, α2/3 functionally selective GABAA receptor positive allosteric modulator. |
| PC-61895 |
Alprazolam
|
Alprazolam (D-65MT, U 31889) is a triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. |
| PC-42117 |
MRK-016
|
MRK-016 (MRK016) is a potent, functionally selective, CNS-penetrating and orally bioavailable inverse agonist of benzodiazepine site of GABAA α5 receptor with Ki of 0.8-1.5 nM for α1-, α2-, α3-, andα5-containing GABAA receptors. |
| PC-22151 |
SL651498
GABAARa agonist
|
SL651498 is a functional selective agonist of alpha2- and alpha3-containing GABAA receptors with high affinity containing alpha(1) (Ki= 6.8 nM) and alpha2 (Ki =12.3 nM) subunits, and weaker affinity for alpha5-containing GABA(A) receptors (Ki=117 nM). |
