| Cat. No. |
Product Name |
Information |
| PC-28087 |
NS-2710
GABAA α3 agonist
|
NS-2710 (NS2710) is a selective, high-efficacy GABAAα3 agonist with Ki of 9.2 nM, has a modest degree of α3 versus α1 selectivity efficacy. |
| PC-28086 |
MRK-067
GABAA agonist
|
MRK-067 (TPA123, TP13) is a high affinity, partial agonist of α1-, α2-, α3-, and α5-containing GABAA receptors with quivalently high affinity (Ki=0.19-0.41 nM). |
| PC-28085 |
FG-7142
Benzodiazepine inverse agonist
|
FG-7142 (FG 7142, ZK 39106, LSU-65) is an anxiogenic benzodiazepine inverse agonist / antagonist, has high affinity for α1 subunit-containing GABAA receptor with Ki of 91 nM, also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit with EC50 of 137 nM. |
| PC-28048 |
YT-III-31
α3βγ2 GABAA PAM
|
YT-III-31 is a selective positive allosteric modulator (PAM) of α3βγ2 GABAA receptor (GABAAR) with EC50 of 153 nM, Emax=917%. |
| PC-25648 |
TPA023B
α2/α3 GABAAR agonist
|
TPA023B (TPA-023B) is selective partial agonist / positive allosteric modulat of GABAA receptor α2/α3 subtype with Ki of 0.73 nM/2 nM respectively, also is an α1 subtype antagonist with Ki of 1.8 nM. |
| PC-25018 |
PZ-II-029
α6 GABAA PAM
|
PZ-II-029 is a selective, positive allosteric modulator (PAM) of α6 subunit-containing GABAA receptor (α6GABAA), potentiates α6β3γ2S GABAA receptor-mediated GABA currents. |
| PC-25017 |
DK-I-56-1
α6 GABAA receptor PAM
|
DK-I-56-1 is a selective positive allosteric modulator (PAM) of α6 GABAA receptors, enhances GABA-induced chloride flux at α6β3γ2, α6β3δ, or α6β3 receptors at sub-µM or low µM concentrations. |
| PC-24259 |
L-838417
⍺2,3,5 GABAA receptor PAM
|
L-838417 (L-838,417) is a potent, ⍺2,3,5-selective GABAA receptor partial agonist/positive allosteric modulator (PAM) and antagonist at the α1, shows binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2 respectively. |
| PC-23986 |
Muscimol
GABA agonist, NINJ1 inhibitor
|
Muscimol (Agarin) is a psychoactive isoxazole and selective neurotransmitter GABA agonist, binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with EC50 of 200 nM, also is a small molecule inhibitor of ninjurin-1 (NINJ1) oligomerization and NINJ1 mediated membrane rupture. |
| PC-22875 |
DDL-920
GABAA receptor NAM
|
DDL-920 is a potent, selective and brain permeable negative allosteric modulator (NAM) of the γ-aminobutyric acid type A receptors (GABARs), inhibits parvalbumin (PV) expressing interneurons (PV+INs) and consequently enhances γ-oscillations both in vitro and in vivo. |
| PC-21943 |
MRK-898
GABAA modulator
|
MRK-898 is an orally active GABA(A) receptor modulator, binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. |
| PC-49338 |
EVT-201
GABAA PAM
|
EVT-201 (Dimdazenil, EVT 201) is a partial positive allosteric GABA(A) receptor modulator with potential for the treatment of insomnia. |
