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Chemical Structure : TPA023B
Catalog No.: PC-62768Not For Human Use, Lab Use Only.
TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype.
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TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype.
TPA023B demonstrates anxiolytic effects in rodent and primate models of anxiety, with no significant effects in ataxia and/or myorelaxation.
| M.Wt | 391.382 | |
| Formula | C21H15F2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Van Laere K, et al. Biol Psychiatry. 2008 Jul 15;64(2):153-61.
2. Russell MG, et al. J Med Chem. 2006 Feb 23;49(4):1235-8.
3. Atack JR, et al. J Psychopharmacol. 2011 Mar;25(3):329-44.
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