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TPA023B

Chemical Structure : TPA023B

CAS No.: 425377-76-0

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TPA023B (TPA 023B)

Catalog No.: PC-62768Not For Human Use, Lab Use Only.

TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype.
    TPA023B demonstrates anxiolytic effects in rodent and primate models of anxiety, with no significant effects in ataxia and/or myorelaxation.

    Physicochemical Properties

    M.Wt 391.382
    Formula C21H15F2N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl) imidazo[1,2-b][1,2,4]triazin-7-yl][1,1'-biphenyl]-2-carbonitrile

    References

    1. Van Laere K, et al. Biol Psychiatry. 2008 Jul 15;64(2):153-61.

    2. Russell MG, et al. J Med Chem. 2006 Feb 23;49(4):1235-8.

    3. Atack JR, et al. J Psychopharmacol. 2011 Mar;25(3):329-44.

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