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Cat. No. Product Name Information
PC-22897

HPK1 PROTAC C3

HPK1 PROTAC

HPK1 PROTAC C3 is a potent, selective and orally active HPK1 PROTAC degrader with DC50 of 21.26 nM, Dmax of 80.50% in Jurkat cells.
PC-22612

BRD9 PROTAC E5

BRD9 PROTAC

BRD9 PROTAC E5 is a highly potent, selective BRD9 PROTAC degrader with DC50 of 16 pM, IC50 of 0.27 nM for antiproliferation in MV4-11 cells.
PC-22591

UNC8153 TFA

NSD2 PROTAC

UNC8153 (UNC 8153) TFA is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces the cellular levels of both NSD2 protein (DC50=350 nM) and the H3K36me2 chromatin mark.
PC-22586

dWIZ-2

WIZ degrader

dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
PC-22381

SKLB-0124

PRMT6 degrader

SKLB-0124 is a selective, first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6) with EC50 of 15.4 uM for HCC827 cells.
PC-22356

GT-653

KDM5B degrader

GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner.
PC-22345

EP300 degrader MC-1

EP300 PROTAC

EP300 degrader MC-1 is a specific, bifunctional small molecule EP300 degrader, preferentially degrades EP300 in a proteasome-dependent manner, does not degrade CREBBP.
PC-22174

MS181

PRC1 degrader

MS181 is a first-in-class CRBN-recruiting and EED-binding (Kd=190 nM) polycomb repressive complex 1 (PRC1) degrader, preferentially degrades PRC1 components BMI1 and RING1B over PRC2 components EZH2 and SUZ12.
PC-22120

ARV-393

BCL6 degrader

ARV-393 is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines.
PC-22055

AU-24118

mSWI/SNF ATPase PROTAC

AU-24118 is a potent, selective, and orally bioavailable degrader of mSWI/SNF ATPases (SMARCA2, SMARCA4) and PBRM1.
PC-21848

GNE-0011

BRD4 degrader

GNE-0011 is a monovalent, JQ1-based BRD4 degrader that is not linked to an E3 ligase binder, triggers proteasomal and ubiquitin-dependent selective degradation of BRD4 over BRD2 and BRD3.
PC-21676

WD6305

METTL3-METTL14 PROTAC

WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line.

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