| Cat. No. |
Product Name |
Information |
| PC-27785 |
Z5000181945
RNF39 degrader
|
Z5000181945 is a small molecule glue degrader of E3 ubiquitin ligase RNF39, enhances the RNF39-CRBN interaction, induces degradation of the RNF39 RING finger domain, which is rescued by the NEDD8-activating enzyme (NAE) inhibitor MLN4924. |
| PC-27784 |
FIZ1 degrader 1
FIZ1 degrader
|
FIZ1 degrader 1 is a small molecule degrader zinc-finger protein FIZ1 (Flt3-interacting zinc finger protein 1). |
| PC-27736 |
DK-5070
GPX4 degrader
|
DK-5070 is a potent, selective UHRF1-recruiting degrader of GPX4 with DC50 of 17.4 nM, Dmax of 84% in in HT1080 cells (24 h). |
| PC-27715 |
dTAGV-1
FKBP12F36V PROTAC
|
dTAGV-1 is a selective FKBP12F36V PORTAC degrader, induces rapid degradation of FKBP12F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduces proliferative capacity of cancer cells, and decreases levels of target proteins. |
| PC-27629 |
DOT1L808
DOT1L PROTAC
|
DOT1L808 is potent and highly selective DOT1L PROTAC degrader with DC50 of 5 nM. |
| PC-27577 |
PinA1
CK1⍺ degrader
|
PinA1 is a potent, preferential molecular glue degrader targeting CK1⍺ with DC50 of 46.9 nM in Jurkat cells (16 h), degrades CK1α via CRBN-dependent ubiquitination. |
| PC-27547 |
dACSL4
ACSL4 degrader
|
dACSL4 is a potent, selective PROTAC degrader targeting ACSL4 (DC50=103 nM, SH-SY5Y cells) by conjugating troglitazone to the CRBN-binding ligand pomalidomide, concurrently degrades ACSL4 and activates PPARγ signaling. |
| PC-27503 |
Sovutrecdeg
TRK degrader
|
Sovutrecdeg (CG001419) is a first-in-class, selective, potent oral degrader of pan-tropomyosin receptor kinase (TRK), selectively degrades both mutant and wild-type TRK proteins. |
| PC-27493 |
Reziciclideg
CDK4/6 degrader
|
Reziciclideg (BTX-9341) is a potent, seletive, blood-brain barrier permeable cereblon-mediated bifunctional degrader of CDK4 and CDK6 with Kd of 31 nM (CDK6). |
| PC-27488 |
SIAIS164018 hydrochloride
Multi-kinases PROTAC
|
SIAIS164018 hydrochloride is a potent, Brigatinib-based PROTAC degrader of multi-kinases ALK, EGFR, FAK, PYK2, PTK6 with IC50 of 2.5 nM and 6.6 nM against ALK and ALK (G1202R), respectively, promotes the ubiquitination and degradation of ALK, EGFR, FAK, PYK2 and PTK6, induces cell cycle arrest at the G1 phase and triggers cell apoptosis. |
| PC-27487 |
SIAIS164018
Multi-kinases PROTAC
|
SIAIS164018 is a potent, Brigatinib-based PROTAC degrader of multi-kinases ALK, EGFR, FAK, PYK2, PTK6 with IC50 of 2.5 nM and 6.6 nM against ALK and ALK (G1202R), respectively, promotes the ubiquitination and degradation of ALK, EGFR, FAK, PYK2 and PTK6, induces cell cycle arrest at the G1 phase and triggers cell apoptosis. |
| PC-27486 |
Omtebrutideg
BTK PROTAC
|
Omtebrutideg is a potent and selective BTK PROTAC degrader. |
