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Cat. No. Product Name Information
PC-22174

MS181

PRC1 degrader

MS181 is a first-in-class CRBN-recruiting and EED-binding (Kd=190 nM) polycomb repressive complex 1 (PRC1) degrader, preferentially degrades PRC1 components BMI1 and RING1B over PRC2 components EZH2 and SUZ12.
PC-22120

ARV-393

BCL6 degrader

ARV-393 is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines.
PC-22055

AU-24118

mSWI/SNF ATPase PROTAC

AU-24118 is a potent, selective, and orally bioavailable degrader of mSWI/SNF ATPases (SMARCA2, SMARCA4) and PBRM1.
PC-21676

WD6305

METTL3-METTL14 PROTAC

WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line.
PC-21653

DAS-CHO-5-oCRBN

c-Src PROTAC

DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 62 nM in CAL148 cells.
PC-21533

KH-103

GR PROTAC

KH-103 is a highly potent, catalytically-driven glucocorticoid receptor (GR) PROTAC degrader, demonstrate excellent performance in passively preventing ligand-induced gene expression activation in the absence of partial agonistic transcriptional triggering and crosstalk inhibition.
PC-21118

HDAC3 PROTAC P7

HDAC3 PROTAC

HDAC3 PROTAC P7 is a potent and selective HDAC3-directed PROTAC with IC50 of 40 nM (HDAC3 deacetylase activity), effectively induces HDAC3 degradation with DC50 of 0.6 nM in THP-1 cells (Emax=90%).
PC-20920

SJ3149

CK1α degrader

SJ3149 (SJ-3149) is uniquely potent and selective CK1α degrader with DC50 of 3.7 nM and Dmax 95% in MOLM-13 cells, potently inhibits the viability of MOLM-13 cells with IC50 of 13 nM.
PC-20886

JQAD1

EP300 degrader

JQAD1 is a potent, selective PROTAC degrader of p300, demonstrate a time-dependent loss of EP300, enhancer acetylation, and transcriptional output in NB cells both in vitro and in vivo.
PC-20885

JET-209

CBP/p300 PROTAC

JET-209 (JET209) is a potent, selective PROTAC degrader of CBP/p300 based on GNE-207 with DC50 of 0.05 nM for CBP and 0.2 nM for p300, Dmax >95% for both proteins in the RS4;11 leukemia cell line.
PC-20693

KT-474

IRAK4 PROTAC

KT-474 (SAR444656, KT474) is a potent, highly selective, orally bioavailable IRAK4 degrader for the treatment of IL-1R/TLR-driven conditions and diseases.
PC-20684

BSJ-04-146

FAK PROTAC

BSJ-04-146 is a potent, selective FAK PROTAC (IC50=26 nM), induces potent and durable FAK degradation in pancreatic and breast cancer cell lines at 10 nM.

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