| Cat. No. |
Product Name |
Information |
| PC-27578 |
PinA1 hydrochloride
CK1⍺ degrader
|
PinA1 hydrochloride is a potent, preferential molecular glue degrader targeting CK1⍺ with DC50 of 46.9 nM in Jurkat cells (16 h), degrades CK1α via CRBN-dependent ubiquitination. |
| PC-27544 |
SMARCA2 4 MGD Compound 1
SMARCA2/4 degrader
|
SMARCA2/4 MGD Compound 1 is a DCAF16-selective molecular glue degrader of SMARCA2/4 with DC50 of 38.1 nM/ 7.1 nM, degrades SMARCA2/4 exclusively via DCAF16, driven by covalent capture of Cys173. |
| PC-27523 |
MD-4251
MDM2 degrader
|
MD-4251 is a potent, selective and orally efficacious MDM2 PROTAC degrader with DC50 of 0.2 nM in RS4;11 cells (Dmax=96% at 2 h), leading to robust p53 activation. |
| PC-27389 |
NE26394
CDK4 degrader
|
NE26394 is a first-in-class, selective molecular glue degrader (MGD) of cyclin-dependent kinase 4 (CDK4) with DC50 of 163 nM and Dmax=93%, induces CDK4 recognition by CRBN depending on the co recruitment of endogenous INK4 family proteins. |
| PC-27387 |
dWBP4-1
WBP4 degrader
|
dWBP4-1 is a potent, highly selective, CRBN-dependent, phenotypically silent molecular glue degrader of spliceosome-associated scaffold protein WBP4 with DC50 of 3.4 nM in in MOLT-4 cells (Dmax=88%, 6h). |
| PC-27354 |
c-MET PROTAC D15
c-MET degrader
|
c-MET PROTAC D15 is a potent, selective and orally active c-MET PROTAC degrader with DC50 of 0.44 nM and 0.35 nM in EBC-1 and Hs746T cells respectively (Dmax >99%). |
| PC-27299 |
SK-3-91
multi-kinase PROTAC
|
SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases), induces protein (YTHDF2, e.g.) degradation through the ubiquitin biotinylation (E-STUB) pathway, degrades YTHDF2 and inhibits cell proliferation and induces morphological changes. |
| PC-27259 |
SD-2301
STAT3 PROTAC
|
SD-2301 is a highly potent, selective, and efficacious STAT3 PROTAC degrader with DC50 of 4 nM, Dmax of >95% in HiBiT assays using HeLa cell line. |
| PC-27236 |
NUCC-0227579
CD73 PROTAC
|
NUCC-0227579 (C79) is a potent, first-in-class CD73 PROTAC degrader with DC50 of 0.32 uM, degrades CD73 via the VHL E3 ligase-dependent proteasomal and lysosomal pathways. |
| PC-27235 |
XZ8078
PARP1/IKZF3 degrader
|
XZ8078 is a potent dual-target degrader targeting PARP1 and IKZF3, shows selectivity over PARP1 and IKZF1, has antiproliferative activities against HR-deficient cancer cells with IC50 of 0.006 nM-39.41 nM. |
| PC-27227 |
APH02174
IRAK4 PROTAC
|
APH02174 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 4.01 nM, Dmax=94%. |
| PC-27226 |
APH003
IRAK4 PROTAC
|
APH003 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 1.28 nM, DC90=6.39 nM. |
