| Cat. No. |
Product Name |
Information |
| PC-24804 |
WZH-17-002
ALK PROTAC
|
WZH-17-002 is a potent, selective ALK PROTAC degrader with DC50 of 25 nM both in H3122 and DFCI076 cells. |
| PC-24767 |
INNO-220
CK1α degrader
|
INNO-220 is a highly selective and potent, CRBN-dependent, orally bioavailable degrader of CK1α without affecting IKZF1/3, impairs cell viability and selectively degraded CK1α in lymphoma cells. |
| PC-24732 |
Aster-A PROTAC NGF3
Aster-A degrader
|
Aster-A PROTAC NGF3 is a VHL-based PROTAC degrader of GRAM domain containing 1A (GRAMD1A, Aster-A) with DC50 of 4.8 uM, Dmax=60%, in HeLa cells. |
| PC-24675 |
Linker-free PROTAC Pro-DA
BCR-ABL degrader
|
Linker-free PROTAC Pro-DA is a linker-free PROTAC degarder of BCR-ABL protein with DC50 of 8 nM in K562 cells, achieving a 93% reduction at 20 nM, shows cell growth IC50 of 0.9 nM. |
| PC-24674 |
Linker-free PROTAC Pro-BA
EML4-ALK degrader
|
Linker-free PROTAC Pro-BA is a linker-free PROTAC degarder of EML4-ALK protein with DC50 of 74 nM and achieves an 82% reduction at 500 nM in H3122 cells, shows cell growth IC50 of 34 nM. |
| PC-24667 |
PRT3789
SMARCA2 degrader
|
PRT3789 is a first-in-class potent and selective SMARCA2 (BRM) degrader with DC50 of 0.72 nM in Hela cells, effectively catalyze the polyubiquitination of specific lysine residues of SMARCA2, resulting in SMARCA2 selective degradation over SMARCA4. |
| PC-24664 |
BMS-986449
IKZF2/4 degrader
|
BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors Helios (IKZF2) and Eos (IKZF4). |
| PC-24663 |
GDC-2992
AR PROTAC
|
GDC-2992 (Compound 28A) is a potent, selective and orally active androgen receptor (AR) PROTAC degrader with DC50 of 2.7 nM, inhibits proliferation with IC50 of 9.7 nM in VCaP cells. |
| PC-24640 |
HDAC7 PROTAC B14
HDAC7 degrader
|
HDAC7 PROTAC B14 is a potent, exceedingly selective HDAC7 PROTAC degrader with DC50 of 25.1 nM in NB4 cells. |
| PC-24575 |
RP03707
KRAS G12D PROTAC
|
RP03707 is a CRBN-involving, highly potent, and selective KRAS G12D PROTAC degrader with DC50 of 0.7 nM in PK-59 cells (Dmax=96%). |
| PC-24558 |
MNK1 PROTAC P11-2
MNK1 PROTAC
|
MNK1 PROTAC P11-2 is a first-in-class, selective MNK1-targeting PROTAC degrader with DC50 of 11.92 nM (MV4-11 cells), Dmax>96%, shows remarkable selectivity for MNK1 over MNK2. |
| PC-24557 |
ERD-1233
ERα degrader
|
ERD-1233 is a potent and orally efficacious PROTAC degrader of estrogen receptor α (ERα) with DC50 of 0.9 nM in MCF-7 cell line, Dmax=100%. |
