| Cat. No. |
Product Name |
Information |
| PC-23403 |
MS105
PTK6 PROTAC
|
MS105 is a potent, selective protein tyrosine kinase 6 (PTK6) ROTAC degrader, specifically and potently degrades PTK6 in a proteasome and VHL-dependent manner with DC50 of 21 nM and Dmax of 84% in MDA-MB-231/LM2-4 cells. |
| PC-23400 |
WEE1-CK1α molecular glue degrader 10
WEE1/CK1α degrader
|
WEE1-CK1α molecular glue degrader 10 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.6 nM and 1.5 nM in MOLT-4 cells respectively. |
| PC-23399 |
WEE1-CK1α molecular glue degrader 1
WEE1/CK1α degrader
|
WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively. |
| PC-23385 |
MD-265
MDM2 PROTAC
|
MD-265 is a potent PROTAC MDM2 degrader, potently inhibits RS4;11 cell line with IC50 of 0.7 nM, induces strong p53 activation in cancer cells carrying wild-type p53. |
| PC-23329 |
BRD9 PROTAC C6
BRD9 PROTAC
|
BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7. |
| PC-23323 |
BET PROTAC SIM1
BRD2 PROTAC
|
BET PROTAC SIM1 is a highly potent, von Hippel-Lindau (VHL)-based BET trivalent PROTAC degrader with preference for BRD2 with DC50 of 1.1 nM, 3.3 nM and 0.7 nM for RD2, BRD3, BRD4 in HEK293 cells, potently inhibits cell viability of MV4;11 AML cell line with IC50 of 1.1 nM (48 h). |
| PC-23305 |
pan-KRAS degrader 4
pan-KRAS PROTAC
|
pan-KRAS degrader 4 is a potent, selective, reversible heterobifunctional pan-KRAS PROTAC degrader with Dmax50 of 17 nM in GP5d cells, efficiently degrades 13 of the 17 most prevalent KRAS mutant alleles and KRASWT with single-digit nanomolar potency. |
| PC-23302 |
SIAIS562055
SOS1 PROTAC
|
SIAIS562055 is a potent, selective SOS1 PROTAC degrader (KD=95.9 nM) which is designed by connecting a CRBN ligand to an analogue of the SOS1 inhibitor BI-3406, selectively degrades SOS1 with DC50 values of 62.5 nM and 8.4 nM in K562 and KU812 cells. |
| PC-23276 |
DD205-291
HPK1 PROTAC
|
DD205-291 is a potent, selective and orally bioavailable PROTAC-based hematopoietic progenitor kinase 1 (HPK1, MAP4K1) degrader with DC50 of 8.8 nM. |
| PC-23265 |
LDD 39
RET degrader
|
LDD 39 is a pyrazolopyridine-based heterobifunctional RET ligand-directed degrader with IC50 of 2.0/1.1/7.5 nM for WT RET/V804M/G810R respectively, and DC50 of 0.97/3.2/6.4 nM in TPC-1 cells against both RET WT and the two mutants. |
| PC-23239 |
SZU-B6
SIRT6 PROTAC
|
SZU-B6 is a highly potent and selective SIRT6 PROTAC degrader with DC50 of 45.29 nM and 154.28 nM in SK-HEP-1 and Huh-7 cells respectively. |
| PC-23233 |
DYR684
DYRK1 PROTAC
|
DYR684 is a potent, and selective PROTAC degrader of DYRK1 with KD of 6.3/16 nM for DYRK1A/DYRK1B, DC50 value of 12.3 nM for DYRK1A in HEK293 cells. |
