| Cat. No. |
Product Name |
Information |
| PC-21143 |
YX968
HDAC3/8 PROTAC
|
YX968 is a potent, selecive HDAC3/8 dual PROTAC degrader with DC50 of 1.7 and 6.1 nM in degrading HDAC3 and HDAC8 respectively (MDA-MD-231 cell, 8 h). |
| PC-21127 |
TD-802
AR PROTAC
|
TD-802 is potent, cereblon-mediated androgen receptor PROTAC degrader, effectively inducs AR protein degradation with DC50 of 12.5 nM and Emax 93% in LNCaP prostate cancer cells. |
| PC-21126 |
ARD-2128
AR PROTAC
|
ARD-2128 is a potent, orally active PROTAC androgen receptor (AR) degrader with DC50 of 0.28 nM in CcaP cell line. |
| PC-21125 |
ARD-2585
AR PROTAC
|
ARD-2585 is a potent and orally bioavailable PROTAC androgen receptor (AR) degrader with DC50 of 0.04 nM, Dmax=99% in VCaP cell line. |
| PC-21124 |
MTX-23
AR PROTAC
|
MTX-23 is a proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) splice variant-7 (AR-V7) and AR-full length (AR-FL) with DC50 of 0.37 and 2 uM, respectively. |
| PC-21116 |
PDCD2 degrader 10e
PDCD2 PROTAC
|
PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity. |
| PC-21068 |
JH-XII-03-02
LRRK2 PROTAC
|
JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S. |
| PC-21045 |
KYH1872
PROTAC
|
KYH1872 is a PROTAC that induces protein degradation via the KLHDC2 E3 ubiquitin ligase, KYH1872 is consisted of a C-terminal fragment of the SelK protein and promiscuous kinase inhibitor YHJ1039 via PGE linker. |
| PC-21044 |
DB0614
PROTAC
|
DB0614 is a CRBN-based PROTAC, induces the degradation of NEK9, FAK, CDK4, CDK6, and WEE1 in cells. |
| PC-20816 |
PTD10
BTK PROTAC
|
PTD10 is a highly potent BTK PROTAC degrader with DC50 of 0.5 nM in TMD8 cells, inhibits cell growth and induces apoptosis more potently than parent molecule GDC-0853. |
| PC-20653 |
DeFer-2
Ferritin PROTAC
|
DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis. |
| PC-73289 |
BSJ-04-132
CDK4 degrader
|
BSJ-04-132 is a selective CDK4 degrader (PROTAC), does not induce IKZF1/3 degradation. |
