| Cat. No. |
Product Name |
Information |
| PC-23566 |
YB-3-17
GSPT1 degrader, mTOR inhibitor
|
YB-3-17 is a potent dual-target, dual-mechanism molecule, robustly inhibits mTOR (IC50=0.22 nM) and selectively degrades GSPT1 (DC50=5 nM, U87 cells). |
| PC-23565 |
LZK PROTAC-21A
LZK PROTAC
|
LZK PROTAC-21A is a potent, selective LZK (Leucine zipper-bearing kinase, MAP3K13)-targeting PROTAC with binding affinity of 35 nM. |
| PC-23554 |
YZ-836P
PRMT5 PROTAC
|
YZ-836P is a CRBN-recruiting PRMT5 PROTAC degrader, exerts cytotoxic effects in TNBC, promotes the ubiquitination and degradation of PRMT5 in a CRBN-dependent manner, downregulates key downstream target protein KLF5 in TNBC. |
| PC-23543 |
dCK1α-2
CK1α degrader
|
dCK1α-2 is a potent, selective and orally bioavailable CK1α degrader with DC50 of 146 nM, Dmax of 84% in MOLM13 cells. |
| PC-23542 |
dCK1α-1
CK1α degrader
|
dCK1α-1 (LC-04-087) is a potent and selective CK1α-targeting molecular glue degrader with DC50 of 12 nM, Dmax of 90% in MOLM13 cells (72 h). |
| PC-23448 |
ATC-324
AR AUTOTAC degrader
|
ATC-324 is a potent, selective androgen receptor (AR) AUTOphagy-TArgeting Chimera (AUTOTAC) degrader with DC50 of 2.05 uM in LNCaP cells, induces the formation of the AR/p62 complex, leading to autophagy-lysosomal degradation of AR. |
| PC-23445 |
TRIB2 PROTAC 5k
TRIB2 PROTAC
|
TRIB2 PROTAC 5k (Compound 5k) is a potent, selective pseudokinase TRIB2 PROTAC degrader with DC50 of 16.8 nM and Dmax of 92% in PC3 cells. |
| PC-23413 |
WIZ degrader 10
WIZ degrader
|
WIZ degrader 10 is a potent, and selective molecular glue degrader of the transcription factor WIZ with DC50 of 3 nM and Dmax of 86%. |
| PC-23400 |
WEE1-CK1α molecular glue degrader 10
WEE1/CK1α degrader
|
WEE1-CK1α molecular glue degrader 10 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.6 nM and 1.5 nM in MOLT-4 cells respectively. |
| PC-23399 |
WEE1-CK1α molecular glue degrader 1
WEE1/CK1α degrader
|
WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively. |
| PC-23385 |
MD-265
MDM2 PROTAC
|
MD-265 is a potent PROTAC MDM2 degrader, potently inhibits RS4;11 cell line with IC50 of 0.7 nM, induces strong p53 activation in cancer cells carrying wild-type p53. |
| PC-23329 |
BRD9 PROTAC C6
BRD9 PROTAC
|
BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7. |
