| Cat. No. |
Product Name |
Information |
| PC-27220 |
DW-229
KDM PROTAC
|
DW-229 is a PROTAC degrader targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs), degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells, shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity. |
| PC-27200 |
JHK-02-108-2
CDK6 PROTAC
|
JHK-02-108-2 is a potent, selective, type II, heterobifunctional CDK6 PROTAC degrader with DC50 of 11 nM in MOLT-4 cells, does not induce CDK5 degradation. |
| PC-27167 |
NSD2 degrader T9
NSD2 degrader
|
NSD2 degrader T9 is a potent, selective, FBXO22-recruiting NSD2 degrader with DC50 of 0.37 uM in in HEK293T-NSD2-HiBiT cells (4 h). |
| PC-27164 |
RAD51 PROTAC G73
RAD51 PROTAC
|
RAD51 PROTAC G73 is an effective RAD51 PROTAC degrader with DC50 of 268 nM in PC-3 cells. |
| PC-27158 |
NSD2-LDD
NSD2 degrader
|
NSD2-LDD is a cereblon-recruiting and PWWP1-mediated ligand directed degrader (LDD) of histone methyltransferase NSD2, selectively and potently eliminates full length and PWWP1 domain containing NSD2 protein isoforms, induces global loss of H3K36me2 and reverses the oncogenic program of t(4;14) multiple myeloma. |
| PC-27137 |
XYD113
GSPT1 degrader
|
XYD113 is a potent and highly selective, orally bioavailable CRBN-dependent GSPT1 molecular glue degrader, exerts potent antiproliferative activity against 22Rv1 cells with IC50 of 69 nM, induces complete degradation of GSPT1 at 111 nM. |
| PC-27121 |
SMD-1087
SMARCA2 PROTAC
|
SMD-1087 is a highly potent, selective SMARCA2 PROTAC degrader with DC50 of 9 nM, with limited activity against SMARCA4. |
| PC-27120 |
SMD-6346
SMARCA2 PROTAC
|
SMD-6346 is a highly potent, selective and orally available SMARCA2 PROTAC degrader with DC50 of 3.3 nM and Dmax > 90%, shows much weaker activity against SMARCA4 (DC50 > 1000 nM, Dmax = 46%). |
| PC-27096 |
HDAC6 PROTAC 15
HDAC6 PROTAC
|
HDAC6 PROTAC 15 is a potent, selective HDAC6 degrader with pDC50 of 9.1 in bronchial epithelium cells, reduces α-tubulin hyperacetylation without affecting histone-3 acetylation. |
| PC-27068 |
JNJ-1013
IRAK1 PROTAC
|
JNJ-1013 is a highly potent, selective interleukin-1 receptor-associated kinase 1 (IRAK1) PROTAC degrader with DC50 of 3 nM in HBL-1 cells, Dmax=96%. |
| PC-26979 |
R4VP
RNF4 degrader
|
R4VP (RNF4-VHL-Protac-like) is a PROTAC-like molecule that induces proteasomal degradation of RNF4, inhibits the proliferation and sphere formation (SFA) of A375R, a human melanoma cell line that is resistant to PLX4032, as well as SCC1 human squamous skin cancer cells. |
| PC-26978 |
CCW 28-3
BRD4 PROTAC
|
CCW 28-3 is a bifunctional BRD4 PROTAC degrader linking RNF4 ligand CCW16 to BET bromodomain family inhibitor JQ1, degrades BRD4 in a proteasome- and RNF4-dependent manner. |
