| Cat. No. |
Product Name |
Information |
| PC-21920 |
CDK9 PROTAC 45
CDK9 PROTAC
|
CDK9 PROTAC 45 is a highly potent, efficacious CDK9 PROTAC degrader, induces cell apoptosis in vitro and inhibits tumor growth in the MDA-MB-231 TNBC model. |
| PC-21882 |
BTX-6654
SOS1 PROTAC degrader
|
BTX-6654 is a potent, selective SOS1 cereblon-based bifunctional PROTAC degrader, reduces downstream signaling markers, pERK and pS6, and displayed antiproliferative activity in cells harboring various KRAS mutations. |
| PC-21848 |
GNE-0011
BRD4 degrader
|
GNE-0011 is a monovalent, JQ1-based BRD4 degrader that is not linked to an E3 ligase binder, triggers proteasomal and ubiquitin-dependent selective degradation of BRD4 over BRD2 and BRD3. |
| PC-21847 |
IBG4
BRD4 degrader
|
IBG4 is a selective, DCAF11-based intramolecular glue/degrader of BRD4, functions via CRL4-DCAF11, shows high specificity for BRD4 and does not efficiently degrade BRD2. |
| PC-21846 |
IBG1
BRD4 degrader
|
IBG1 is a PROTAC-like, specific degrader of BET bromodomain BRD2 and BRD4 with DC50 of 0.15 nM (BRD4), which comprises the BET family bromodomain inhibitor JQ1 tethered to E7820. |
| PC-21776 |
dEALK1
ALK PROTAC
|
dEALK1 is a small-molecule degrader of EML4-ALK fusion proteins with binding constant (Kd) value of 44 nM for kinase domain of recombinant ALK, overcomes resistance to ALK inhibitor ceritinib. |
| PC-21717 |
Chk1 PROTAC-2
Chk1 PROTAC
|
Chk1 PROTAC-2 is a potent Chk1 degrader with DC50 of 1.33 µM in A375 cells. |
| PC-21708 |
PROTAC dCE-1
CBP/EP300 degrader
|
PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells. |
| PC-21676 |
WD6305
METTL3-METTL14 PROTAC
|
WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line. |
| PC-21662 |
ACBI3
pan-KRAS PROTAC
|
ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells). |
| PC-21652 |
DAS-5-oCRBN
c-Src PROTAC
|
DAS-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 3 nM, without effect on Bcr-Abl. |
| PC-21642 |
DBr-1
DCAF1-BRD9 PROTAC
|
DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder. |
