| Cat. No. |
Product Name |
Information |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-22505 |
ZXH-8-004
DENV E protein degrader
|
ZXH-8-004 is a selective and potent PROTAC degrader of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.
ZXH-8-004 is cell permeable and able to engage the CRL4CRBN E3 ligase. |
| PC-22493 |
FAK degrader F2
FAK degrader
|
FAK PROTAC F2 is a potent, selective FAK CRBN-recruiting PROTAC degrader based on the FAK inhibitor Ifebemtinib (IN10018) with DC50 of 27.72 nM and 60.10 nM for total FAK and phosphorylated FAK in MDA-MB-231 cells. |
| PC-22486 |
XYD129
CBP/p300 degrader
|
XYD129 is a highly potent and selective CBP/p300 degrader with IC50 of 21/30 nM, effectively degrades CBP/p300 proteins and exhibits potent inhibition of growth in acute leukemia cell lines (MOLM-16, IC50=7.4 nM). |
| PC-22441 |
ARM165
PIK3CG/p110γ degrader
|
ARM165 is a proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically degrades PIK3CG/p110γ, specifically degrades PIK3CG and potently suppresses AML. |
| PC-22429 |
R1-ICR-5
RIPK1 degrader
|
R1-ICR-5 is a selective and potent RIPK1 PROTAC degrader, triggers VHL-mediated degradation of RIPK1, deregulates TNFR1 and TLR3 signaling, enhances innate immune signaling and necroptosis |
| PC-22413 |
AN2
mHTT degrader
|
AN2 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT. |
| PC-22412 |
AN1
mHTT degrader
|
AN1 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT. |
| PC-22411 |
HL435
BRD4 degrader
|
HL435 is a potent, alkenyl oxindole-based heterobifunctional BRD4 degrader PROTAC with DC50 values of 11.9 and 21.9 nM in MDA-MB-231 and MCF-7 cells, respectively. |
| PC-22394 |
MS140
CDK4/6 degrader
|
MS140 is a potent and selective, CRBN-dependent CDK4/6-degrader (PROTAC) with IC50 of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, suppresses Rb/E2F signaling and reduces CDK4 and CDK6 protein levels. |
| PC-22393 |
WEE1/CK1α degrader 2
WEE1/CK1α degrader
|
WEE1/CK1α degrader 2 is a highly potent WEE1/CK1α molecular glue degrader with DC50 of 1.6/1.5 nM, respectively, Emax >98%. |
| PC-22392 |
WEE1/CK1α degrader 1
WEE1/CK1α degrader
|
WEE1/CK1α degrader 1 is a highly potent WEE1/CK1α molecular glue degrader with DC50 of 1.1/3.1 nM, respectively. |
