| Cat. No. |
Product Name |
Information |
| PC-24058 |
RDN8011
KDM4 PROTAC
|
RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D. |
| PC-24047 |
KT-333
STAT3 degrader
|
KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines. |
| PC-24046 |
CDK9 PROTAC C3
CDK9 degrader
|
CDK9 PROTAC C3 is a potent and selective, oral CDK9 PROTAC degrader with DC50 of 1.09 nM in NCI-H69 cells. |
| PC-24021 |
NRX-0492
BTK PROTAC
|
NRX-0492 is a potent, selective cereblon (CRBN)-basesd PROTAC degrader of wild-type and C481 mutant BTK with DC50 of 0.1 nM and 0.2 nM, and DC90 of 0.3 nM and 0.5 nM in TMD8 cells expressing WT or C481S mutant BTK respectively. |
| PC-23960 |
QXG-6442
CK1α PROTAC
|
QXG-6442 is a potent, selective casein kinase 1 alpha (CK1α) degrader with DC50 value of 5.7 nM and Dmax of 90% in in MOLT-4 cells. |
| PC-23948 |
TD-522
GSPT1 degrader
|
TD-522 is a potent, selective GSPT1 degrader, ffectively induces GSPT1 degradation with DC50 of 0.269 nM and Dmax of >95 % at 10 nM in KG-1 cells. |
| PC-23947 |
AN5777
GSPT1 degrader
|
AN5777 is a potent GSPT1 degrader, binds recombinant CRBN and induces GSPT1 degradation through the UPS. |
| PC-23946 |
LYG-409
GSPT1 degrader
|
LYG-409 is a potent, selective, and orally bioavailable GSPT1 molecular glue degrader with DC50 of 7.87 nM in KG-1 cells. |
| PC-23899 |
AH078
CK1δ /CK1ε PROTAC
|
AH078 is a potent, highly selective PROTAC degrader of CK1δ and CK1ε with DC50 of 200 nM (CK1δ) in HEK293 cells, shows excellent selectivity over the highly related CK1α isoform. |
| PC-23854 |
HDAC6 PROTAC A6
HDAC6 PROTAC
|
HDAC6 PROTAC A6 is a potent, selective HDAC6 PROTAC degrader with DC50 of 3.5 nM, Dmax values of over 80% in HL-60 cells. |
| PC-23853 |
FF2049
HDAC1-3 PROTAC
|
FF2049 is a first-in-class, selective Fem-1 homologue B (FEM1B)-recruiting HDAC1-3 PROTAC degrader with DC50 value of 257 nM and Dmax of 85% (HDAC1) in MM.1S cells. |
| PC-23842 |
SJ995973
BET PROTAC
|
SJ995973 is a highly potent PROTAC degrader of bromodomain and extra-terminal (BET) proteins with DC50 of 0.87 nM in MV4-11 cells (BRD4) and Dmax=99%, inhibits viability of MV4-11 cells with IC50 of 3 pM. |
