| Cat. No. |
Product Name |
Information |
| PC-26138 |
KTX-582
IRAK4 PROTAC
|
KTX-582 is a potent, selective IRAK4 PROTAC degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively, induces apoptosis in MYD88MT DLBCL, induces in vivo tumor regressions in lymphoma model. |
| PC-26133 |
GDCNF-11
GPX4 degrader
|
GDCNF-11 is a potent HSP90 interactome-mediated proteolysis targeting chimera (HIM-PROTAC) GPX4 degarder, potently induces ferroptosis via HSP90-mediated ubiquitin-proteasomal degradation of GPX4 in HT-1080 cells with DC50 of 0.08 uM. |
| PC-26131 |
GDAz-3
GPX4 degrader
|
GDAz-3 is a potent GPX4-targeting HSP70-PROTAC, potently and rapidly eliminates GPX4 in HT1080 cells (DC50=0.13 uM), thereby triggering ferroptosis with high selectivity. |
| PC-26015 |
CCT400028
Aurora A PROTAC
|
CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling. |
| PC-25972 |
WWZ-11-098
CDK6 degrader
|
WWZ-11-098 is a potent, selective Palbociclib-based CDK6 degrader with DC50 of 2.6 nM and Dmax of 99.9 % in MOLT4 cells via CRBN-dependent manner, while sparing CDK1, CDK2, CDK4, and CDK9. |
| PC-25951 |
NP1192
NAT10 PROTAC
|
NP1192 is a highly effective PROTAC degrader targeting NAT10, promotes NAT10 KD and inhibits ac4C modification, facilitates NAT10 degradation through the ubiquitin-proteasome system (UPS). |
| PC-25907 |
CPD-2828
IRE1α PROTAC
|
CPD-2828 is the first PROTAC degrader of IRE1α with DC50 of 0.43 uM in HEK293T cell, exhibits CRBN binding IC50 of 0.65 uM. |
| PC-25892 |
CDK6 PROTAC 48a
CDK6 PROTAC
|
CDK6 PROTAC 48a is a potent, selective, KLHDC2-mediated CDK6 PROTAC degrader with DC50 of 37 nM in MOLM-14 cells, selectively degrades CDK6 among 8642 proteins and within the CDK family. |
| PC-25887 |
PLK4 PROTAC SP27
PLK4 PROTAC
|
PLK4 PROTAC SP27 is a potent, selective PLK4 proteolysis targeting chimera (PROTAC) degrader with binding IC50 of 8.4 nM for PLK4, DC50 of 19.5 nM in MCF-7 cells. |
| PC-25872 |
dCDK9-202
CDK9 PROTAC
|
dCDK9-202 is a highly potent, selective PROTAC CDK9 degrader with DC50 of 3.5 nM and CDK9 decline (94.4%) at 25 nM in TC-71 cell line, inhibits cell growth with IC50 of 8.5 nM in TC-71 cells. |
| PC-25871 |
LAG-3 PROTAC-1
LAG-3 PROTAC
|
LAG-3 PROTAC-1 is a potent, efficacious PROTAC) degrader of immune checkpoint receptor lymphocyte activation gene-3 (LAG-3) with DC50 of 0.27 uM in Raji-LAG3 cells (24 h). |
| PC-25869 |
LD-110
LSD1 PROTAC
|
LD-110 is a potent and efficacious PROTAC) degrader of LSD1 with DC50 of 0.44, 1.18, and 1.24 μM in the KYSE-150, KYSE-30, and EC9706, respectively. |
