JNJ-1013 is a highly potent, selective interleukin-1 receptor-associated kinase 1 (IRAK1) PROTAC degrader with DC50 of 3 nM in HBL-1 cells, Dmax=96%. JNJ-1013inhibits cell proliferation of HBL-1 cells with IC50 of 0.06 uM. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 potently inhibited IRAK1 downstream signaling pathways and demonstrated strong anti-proliferative effects in ABC DLBCL cells with MyD88 mutation.
