| Cat. No. |
Product Name |
Information |
| PC-24665 |
GSK4418959
WRN inhibitor
|
GSK4418959 (IDE275) is a potent, non-covalent, reversible Werner helicase (WRN) inhibitor, binds to WRN in an allosteric pocket and inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. |
| PC-24067 |
SAR-24
PCNA inhibitor
|
SAR-24 (PCNA-I1S) is a small molecule inhibitor of proliferating cell nuclear antigen (PCNA), significantly affects chromatin-associated PCNA in tumor cells, effectively decreasing its levels and thereby inhibiting cancer cell proliferation. |
| PC-24057 |
KWR137
WRN inhibitor
|
KWR137 is a novel potent inhibitor of Werner protein WRN with IC50 of 8 nM (WRN ATPase). |
| PC-24056 |
KWR095
WRN inhibitor
|
KWR095 is a novel potent inhibitor of Werner protein WRN with IC50 of 32 nM (WRN ATPase). |
| PC-23997 |
SU0547
SMUG1 activator
|
SU0547 is a specific small-molecule activator of DNA repair enzyme SMUG1 (Single-Strand-Selective Monofunctional Uraci-DNA Glycosylase 1) with AC50 of 4.3 uM, activates SMUG1 by more than 40-fold in vitro. |
| PC-23727 |
MU147
MRE11 inhibitor
|
MU147 is a specific small molecule inhibitor of MRE11 nuclease with IC50 of 25.3 uM, inhibits MRE11-RAD50-NBS1 (MRN)-dependent homologous recombination. |
| PC-23726 |
MU1409
MRE11 inhibitor
|
MU1409 is a specific small molecule inhibitor of MRE11 nuclease with IC50 of 12.1 uM, inhibits MRE11-RAD50-NBS1 (MRN)-dependent homologous recombination. |
| PC-22696 |
MUS81 inhibitor 23
MUS81 inhibitor
|
MUS81 inhibitor 23 is a small molecule inhibitor of DNA repair endonuclease Mus81 with IC50 of 0.32 uM and SPR Kd of 0.67 uM (MUS81-EME1). |
| PC-22445 |
SNM1A inhibitor 19
SNM1A inhibitor
|
SNM1A inhibitor 19 is a cell-active small molecule inhibitor of SNM1A DNA repair nuclease with IC50 of 44 uM, sensitises cancer cells to cisplatin and delays resolution of cisplatin-induced DNA damage. |
| PC-22201 |
NUDT5/NUDT14 inhibitor 9
NUDT5/NUDT14 inhibitor
|
NUDT5/NUDT14 inhibitor 9 is a potent dual cell-active NUDT5/NUDT14 inhibitor with SPR KD of 400 nM for purified human NUDT14 protein. |
| PC-22121 |
VVD-133214
WRN inhibitor
|
VVD-133214 (VVD214, RO7589831) is a potent, selective, covalent allosteric inhibitor of WRN helicase, covalently engages cysteine 727 of WRN in a nucleotide cooperative manner and inhibits ATP hydrolysis and helicase activity. |
| PC-22110 |
GSK_WRN4
WRN inhibitor
|
GSK_WRN4 (WRNi, GSK-WRN4) is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 7.6, covalently targets WRN Cys727 residue. |
