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Cat. No. Product Name Information
PC-22696

MUS81 inhibitor 23

MUS81 inhibitor

MUS81 inhibitor 23 is a small molecule inhibitor of DNA repair endonuclease Mus81 with IC50 of 0.32 uM and SPR Kd of 0.67 uM (MUS81-EME1).
PC-22445

SNM1A inhibitor 19

SNM1A inhibitor

SNM1A inhibitor 19 is a cell-active small molecule inhibitor of SNM1A DNA repair nuclease with IC50 of 44 uM, sensitises cancer cells to cisplatin and delays resolution of cisplatin-induced DNA damage.
PC-22110

GSK_WRN4

WRN helicase inhibitor

GSK_WRN4 (WRNi, GSK-WRN4) is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 7.6, covalently targets WRN Cys727 residue.
PC-22109

GSK_WRN3

WRN helicase inhibitor

GSK_WRN3 (WRNi, GSK-WRN3) is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 8.6, covalently targets WRN Cys727 residue.
PC-22108

GSK_WRN2

WRN helicase inhibitor

GSK_WRN2 is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 6.5, covalently targets WRN Cys727 residue.
PC-22107

GSK_WRN1

WRN helicase inhibitor

GSK_WRN1 is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 5.8, covalently targets WRN Cys727 residue.
PC-20533

MTH1 inhibitor AZ19

MTH1 inhibitor

MTH1 inhibitor AZ19 is a highly potent MTH1 inhibitor with IC50 of 0.9 nM and Kd of 0.5 nM, displays EC50 of 7 nM in whole cell thermal stability assay in K562 cells.

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