| Cat. No. |
Product Name |
Information |
| PC-45105 |
TH-287 hydrochloride
MTH1 inhibitor
|
TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-45104 |
TH-287
MTH1 inhibitor
|
TH-287 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-24739 |
WRN inhibitor 40
WRN inhibitor
|
WRN inhibitor 40 is a potent, selective and covalent WRN helicase inhibitor with IC50 of 3.7 nM in WRN unwinding assay, targets WRN Cys727. |
| PC-24066 |
ATX-101
PCNA inhibitor
|
ATX-101 is an APIM-containing cell-penetrating peptide targeting PCNA, impairs the APIM-PCNA interaction. |
| PC-23728 |
PFM03
MRE11 inhibitor
|
PFM03 is a specific MRE11 endonuclease inhibitor, affects DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ). |
| PC-22774 |
HDGFRP2 PWWP domain inhibitor BBP
HDGFRP2 PWWP inhibitor
|
BBP is a small molecule inhibitor of the hepatoma-derived growth factor-related protein 2 (HDGFRP2) PWWP domain, dually targets both HDGFRP2 and PSIP1 PWWP domains, engage with the aromatic cage of the HDGFRP2 PWWP domain. |
| PC-22697 |
MUS81 inhibitor 24
MUS81 inhibitor
|
MUS81 inhibitor 24 is a small molecule inhibitor of DNA repair endonuclease Mus81 with IC50 of 0.27 uM and SPR Kd of 1.1 uM (MUS81-EME1). |
| PC-22107 |
GSK_WRN1
WRN helicase inhibitor
|
GSK_WRN1 is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 5.8, covalently targets WRN Cys727 residue. |
| PC-20533 |
MTH1 inhibitor AZ19
MTH1 inhibitor
|
MTH1 inhibitor AZ19 is a highly potent MTH1 inhibitor with IC50 of 0.9 nM and Kd of 0.5 nM, displays EC50 of 7 nM in whole cell thermal stability assay in K562 cells. |
