| Cat. No. |
Product Name |
Information |
| PC-45763 |
(Z)-Mirin
MRE11 inhibitor
|
(Z)-Mirin is a small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity. |
| PC-42079 |
HUHS-015
PCA-1/ALKBH3 inhibitor
|
HUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM. |
| PC-43227 |
TH-588 hydrochloride
MTH1 inhibitor
|
TH-588 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM. |
| PC-43226 |
TH-588
MTH1 inhibitor
|
TH-588 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM. |
| PC-45105 |
TH-287 hydrochloride
MTH1 inhibitor
|
TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-45104 |
TH-287
MTH1 inhibitor
|
TH-287 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-26950 |
NCGC00029283
WRN inhibitor
|
NCGC00029283 is a specific small molecule inhibitor of Werner Syndrome helicase-nuclease (WRN) with IC50 of 2.3 uM, 12.5 uM and 3.4 uM for WRN, BLM and FANCJ. |
| PC-26135 |
ART5537
EXO1 inhibitor
|
ART5537 (ART-5537) is highly potent and selective inhibitor of Exonuclease 1 (EXO1) with IC50 of 3.4 nM, inhibits homologous recombination (HR) with EC50 of 7.2 nM in HR reporter assays. |
| PC-26081 |
MU876
MUS81 inhibitor
|
MU876 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.52 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells. |
| PC-26080 |
MU262
MUS81 inhibitor
|
MU262 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.87 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells. |
| PC-25461 |
WRN degrader 14c
WRN degrader
|
WRN degrader 14c is a potent, selective degrader of Werner syndrome helicase (WRN) with DC50 of 1.7 uM in MSI-H HCT116 cells, covalently conjugates to C727 within the WRN helicase domain, forming an adamantane-tagged adduct that initiates sustained proteasomal degradation. |
| PC-24739 |
WRN inhibitor 40
WRN inhibitor
|
WRN inhibitor 40 is a potent, selective and covalent WRN helicase inhibitor with IC50 of 3.7 nM in WRN unwinding assay, targets WRN Cys727. |
