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TH-287 hydrochloride

Chemical Structure : TH-287 hydrochloride

CAS No.: 1638211-05-8

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TH-287 hydrochloride (TH287 hydrochloride)

Catalog No.: PC-45105Not For Human Use, Lab Use Only.

TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM.
TH-287 shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity.
TH-287 causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

Physicochemical Properties

M.Wt 305.5909
Formula C11H11Cl3N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-, hydrochloride (1:1)

References

1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.

2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.

3. Kawamura T, et al. Sci Rep. 2016 May 23;6:26521.

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