| Cat. No. |
Product Name |
Information |
| PC-24037 |
AP503
GPR133 agonist
|
AP503 (AP-970/43482503) is a potent, specific small molecule agonist of androgen membrane receptor GPR133 (ADGRD1) with EC50 of 1.21 nM. |
| PC-22067 |
SC912
AR-V7 inhibitor
|
SC912 is a small molecule inhibitor of androgen receptor AR-V7, binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD), disruptes AR-V7 transcriptional activity, impairs AR-V7 nuclear localization and DNA binding. |
| PC-21578 |
AR NTD inhibitor 16
AR NTD inhibitor
|
AR NTD inhibitor 16 is a small molecule inhibitor of androgen receptor N-terminal domain (AR NTD) with IC50 of 0.12 uM in VCaP cell-based GRE2-luciferase reporter gene assays. |
| PC-21406 |
UT-155
AR inhibitor
|
UT-155 is a potent and selective androgen receptor (AR) degrader (SARD), binds to AR-LBD (Ki=267 nM), degrades and inhibits AR and AR splice variants (AR-SVs), including AR-V7. |
| PC-49597A |
UT-215
AR antagonist
|
UT-215 (UT215) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR. |
| PC-20115 |
ET516
AR inhibitor
|
ET516 is a potent androgen receptor liquid-liquid phase separation (AR LLPS) inhibitor, specifically disrupts AR condensates, effectively suppresses AR transcriptional activity and inhibits the proliferation and tumor growth of prostate cancer cells expressing AR-resistant mutants. |
| PC-20039 |
Gumelutamide
AR inhibitor
|
Gumelutamide (TAS3681) is a potent, selective androgen receptor (AR) pure antagonist with Ki of 7.39 and 23.8 nM for WT AR and AR T878A mutant respectively, inhibits AR transcriptional activity and downregulates AR-full length (AR-FL) and AR-Vs. |
| PC-20032 |
Faznolutamide
AR inhibitor
|
Faznolutamide is a potent, selective androgen receptor (AR) antagonist. |
| PC-49722 |
Vosilasarm
SARM
|
Vosilasarm (RAD-140, EP0062) is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM), shows excellent affinity for the androgen receptor (Ki=7 nM). |
| PC-49597 |
UT-143
Androgen Receptor inhibitor
|
UT-143 (UT143) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR. |
| PC-49412 |
EPI-7170
AR-NTD inhibitor
|
EPI-7170 is a potent next-generation analog of Ralaniten (EPI-002) and inhibitor of androgen receptor N-terminal domain (AR-NTD), inhibits androgen-induced PSA-luciferase activity in transiently transfected LNCaP cells with IC50 of 1.08 uM. |
| PC-49173 |
JJ-450
AR inhibitor
|
JJ-450 is a novel analogue of IMTPPE and direct and specific inhibitor of androgen receptor (AR) transcriptional activity, blocks AR recruitment to androgen-responsive elements and suppresses AR target gene expression. |
