| Cat. No. |
Product Name |
Information |
| PC-24015 |
RU 58841
Androgen receptor antagonist
|
RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen, shows potential for androgen-dependent skin disorders such as acne, androgenetic alopecia and hirsutism. |
| PC-23465 |
AR antagonist BG-15n
AR antagonist
|
AR antagonist BG-15n is a novel small molecule androgen receptor (AR) antagonist, binds to the ligand-binding domain of AR, promotes AR localization to the nucleus, yet potently and selectively down-regulates AR-target genes. |
| PC-23464 |
AR antagonist BG-15a
AR antagonist
|
AR antagonist BG-15a is a novel small molecule androgen receptor (AR) antagonist, binds to the ligand-binding domain of AR, promotes AR localization to the nucleus, yet potently and selectively down-regulates AR-target genes. |
| PC-22862 |
AR modulator 1
SARM
|
AR modulator 1 is a potent, selective androgen receptor modulator (SARM). |
| PC-22814 |
EPI-7386
AR NTD inhibitor
|
EPI-7386 (Masofaniten) is a next-generation androgen receptor N-terminal domain (AR NTD) inhibitor, inhibits AR activity by binding the N-terminal domain (NTD) and blocking transcription, irrespective of ligand-binding domain resistance mechanisms. |
| PC-22037 |
Bicalutamide
AR inhibitor
|
Bicalutamide (ICI 176,334) is an orally active non-steroidal androgen receptor (AR) antagonist for treatment of prostate cancer. |
| PC-21883 |
(+)-JJ-74-138
Androgen Receptor inhibitor
|
(+)-JJ-74-138 is a non-competitive androgen receptor (AR) antagonist, directly interacts with AR with SPR KD of 4.29 uM, inhibits AR with mutations in the LBD or lacking ligand binding domain (LBD). |
| PC-21502 |
AR inhibitor 1ae
AR inhibitor
|
AR inhibitor 1ae is a small-molecule inhibitor of the androgen receptor activation domain (AR AD) with IC50 of 1.54 uM in androgen-induced PSA-luciferase assays, inhibits AR-V7 transcriptional activity with IC50 of 4.1 uM. |
| PC-21406 |
UT-155
AR inhibitor
|
UT-155 is a potent and selective AR degrader (SARD), binds to AR-LBD (Ki=267 nM), degrades and inhibits AR and AR splice variants (AR-SVs), including AR-V7. |
| PC-21405 |
UT-34
AR inhibitor
|
UT-34 is a potent, second-generation androgen receptor (AR) pan antagonist, degrades enzalutamide-sensitive and -resistant ARs and AR splice variants (AR-SVs). |
| PC-21404 |
UT-105
AR inhibitor
|
UT-105 is a small-molecule, irreversible, selective androgen receptor (AR) degrader (SARD) and irreversible inhibitor, binds to AR N-terminal domain (NTD) and inhibits both the AR and AR splice variants (AR-SVs). |
| PC-20797 |
M17-B15
AR inhibitor
|
M17-B15 is a potent, specific small molecule inhibitor of androgen receptor (AR) targeting the dimer interface pocket (DIP), inhibits AR transcriptional inhibition with IC50 of 0.03 uM. |
