| Cat. No. |
Product Name |
Information |
| PC-49597 |
UT-143
Androgen Receptor inhibitor
|
UT-143 (UT143) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR. |
| PC-49412 |
EPI-7170
AR-NTD inhibitor
|
EPI-7170 is a potent next-generation analog of Ralaniten (EPI-002) and inhibitor of androgen receptor N-terminal domain (AR-NTD), inhibits androgen-induced PSA-luciferase activity in transiently transfected LNCaP cells with IC50 of 1.08 uM. |
| PC-49173 |
JJ-450
AR inhibitor
|
JJ-450 is a novel analogue of IMTPPE and direct and specific inhibitor of androgen receptor (AR) transcriptional activity, blocks AR recruitment to androgen-responsive elements and suppresses AR target gene expression. |
| PC-38370 |
Rezvilutamide
Androgen Receptor inhibitor
|
Rezvilutamide (SHR3680) is a novel and pure androgen-receptor (AR) antagonist that shows potent antitumor activity against castration-resistant prostate cancer (CRPC) but with much less brain distribution than enzalutamide. |
| PC-73372 |
A4B17
BAG1L-AR NTD inhibitor
|
A4B17 is a small molecule that inhibits BAG1L-AR NTD interaction, inhibits the proliferation of AR positive prostate cancer cells. |
| PC-73220 |
Pyrilutamide
AR antagonist
|
Pyrilutamide (KX826) is an androgen receptor (AR) antagonist and a potential first-in-class topical drug for the treatment of androgenetic alopecia (AGA) and acne vulgaris. |
| PC-73182 |
Apalutamide
AR antagonist
|
Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist with binding IC50 of 16 nM. |
| PC-72753 |
VPC-13789
Androgen receptor inhibitor
|
VPC-13789 (VPC13789) is a potent, selective, orally available inhibitor of androgen receptor binding function-3 (BF3) site with IC50 of 0.19 uM. |
| PC-72512 |
JNJ-pan-AR
AR inhibitor
|
JNJ-pan-AR is a highly potent, selective antagonist of androgen receptor (AR) wild-type and F877L mutant for the treatment of the F877L mutant and wild-type CRPC. |
| PC-72511 |
JNJ-63576253
AR inhibitor
|
JNJ-63576253 (TRC-253, JNJ63576253) is a next-generation, potent, selective androgen receptor (AR) antagonist (inhibitor) against wild-type AR (IC50=6.9 nM), AR F877L and other clinically detected ligand binding domain (LBD) point mutations. |
| PC-35866 |
IMTPPE
AR inhibitor
|
IMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells. |
| PC-35680 |
KCI807
AR-ELK1 inhibitor
|
KCI807 (KCI-807) is a small molecule that selectively disrupts ELK1-dependent promoter activation by wild-type and variant androgen receptors (IC50=0.53 uM) without interfering with ELK1 activation by ERK. |
