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You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Androgen Receptor (AR)-VPC-13789
VPC-13789

Chemical Structure : VPC-13789

CAS No.: 2761146-51-2

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VPC-13789 (VPC13789)

Catalog No.: PC-72753Not For Human Use, Lab Use Only.

VPC-13789 (VPC13789) is a potent, selective, orally available inhibitor of androgen receptor binding function-3 (BF3) site with IC50 of 0.19 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VPC-13789 (VPC13789) is a potent, selective, orally available inhibitor of androgen receptor binding function-3 (BF3) site with IC50 of 0.19 uM.
VPC-13789 suppresses AR-mediated transcription, chromatin binding, and recruitment of coregulatory proteins.
VPC-13789 selectively reduces the growth of both androgen-dependent and enzalutamide-resistant PCa cell lines.
VPC-13789 demonstrated in vitro efficacy that reduced PSA production and tumor volume in animal models of CRPC with no observed toxicity.

Physicochemical Properties

M.Wt 383.37
Formula C21H16F3N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-isopropyl-2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline-5-carboxamide

References

1. Eric Leblanc, et al. J. Med. Chem. 2021, 64, 20, 14968–14982.

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