Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Androgen Receptor (AR)-VPC-13789
VPC-13789

Chemical Structure : VPC-13789

CAS No.: 2761146-51-2

Add to Favorites

VPC-13789 (VPC13789)

Catalog No.: PC-72753Not For Human Use, Lab Use Only.

VPC-13789 (VPC13789) is a potent, selective, orally available inhibitor of androgen receptor binding function-3 (BF3) site with IC50 of 0.19 uM.

Packing Price Stock Quantity
25 mg Get quote
100 mg Get quote
250 mg Get quote
1 g Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VPC-13789 (VPC13789) is a potent, selective, orally available inhibitor of androgen receptor binding function-3 (BF3) site with IC50 of 0.19 uM.
VPC-13789 suppresses AR-mediated transcription, chromatin binding, and recruitment of coregulatory proteins.
VPC-13789 selectively reduces the growth of both androgen-dependent and enzalutamide-resistant PCa cell lines.
VPC-13789 demonstrated in vitro efficacy that reduced PSA production and tumor volume in animal models of CRPC with no observed toxicity.

Physicochemical Properties

M.Wt 383.37
Formula C21H16F3N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-isopropyl-2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline-5-carboxamide

References

1. Eric Leblanc, et al. J. Med. Chem. 2021, 64, 20, 14968–14982.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: