| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-49048 |
ONX0801
|
501332-69-0 |
ONX 0801 (Idetrexed, CT900, BGC 945) is a small molecule thymidylate synthase (TS) inhibitor, can be selectively transported to tumor cells via α-folate receptor (α-FR, KD=1 nM), but not the physiological reduced-folate carrier system (RFC). |
| PC-72940 |
TH9619
|
2379556-22-4 |
TH9619 (TH-9619) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 47 nM. |
| PC-49578 |
Thymidylate synthase destabilizer E7
|
|
Thymidylate synthase destabilizer E7 is a small molecule human thymidylate synthase (hTS) destabilizer, binds at the monomer-monomer interface and shifts the dimerization equilibrium of both the recombinant and the intracellular protein toward the inactive monomers. |
| PC-49050 |
AGF94
|
136784-51-5 |
AGF94 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis. |
| PC-49049 |
AGF154
|
1286279-90-0 |
AGF154 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis. |
| PC-49047 |
Plevitrexed
|
153537-73-6 |
Plevitrexed (ZD 9331, BGC 9331)a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM, selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, causes DNA synthesis inhibition and apoptosis. |
| PC-47090 |
TH7299
|
1415648-20-2 |
TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM, TH7299 is
highly selective towards MTHFD2 (IC50=254 nM) over other enzymes involved in 1C-metabolism (i.e. SHMT1/2, TS and DHFR). |
