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Cat. No. Product Name CAS No. Information
PC-49048

ONX0801

501332-69-0 ONX 0801 (Idetrexed, CT900, BGC 945) is a small molecule thymidylate synthase (TS) inhibitor, can be selectively transported to tumor cells via α-folate receptor (α-FR, KD=1 nM), but not the physiological reduced-folate carrier system (RFC).
PC-72940

TH9619

2379556-22-4 TH9619 (TH-9619) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 47 nM.
PC-49578

Thymidylate synthase destabilizer E7

Thymidylate synthase destabilizer E7 is a small molecule human thymidylate synthase (hTS) destabilizer, binds at the monomer-monomer interface and shifts the dimerization equilibrium of both the recombinant and the intracellular protein toward the inactive monomers.
PC-49050

AGF94

136784-51-5 AGF94 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis.
PC-49049

AGF154

1286279-90-0 AGF154 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis.
PC-49047

Plevitrexed

153537-73-6 Plevitrexed (ZD 9331, BGC 9331)a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM, selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, causes DNA synthesis inhibition and apoptosis.
PC-47090

TH7299

1415648-20-2 TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM, TH7299 is
highly selective towards MTHFD2 (IC50=254 nM) over other enzymes involved in 1C-metabolism (i.e. SHMT1/2, TS and DHFR).

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